Vascular effects of epinephrine, lisinopril, and chlorpromazine in diabetic and non-diabetic rats

Basit Öğe Kaydı
dc.contributor.authorAygit, AC
dc.contributor.authorAyhan, MS
dc.contributor.authorDemiralay, A
dc.contributor.authorYildirim, I
dc.date.accessioned2024-06-12T11:19:29Z
dc.date.available2024-06-12T11:19:29Z
dc.date.issued1999
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this study, the vascular responses of diabetic rat femoral arteries to epinephrine were investigated. The effects of lisinopril (ACE inhibitor) on vascular epinephrine sensitivity were also tested in a different group. This study was carried out in sodium pentobarbital-anesthetized rats 8 weeks after induction of diabetes with streptozotocin. After extensive dissection of the femoral arteries with adventitial stripping, epinephrine and chlorpromazine were applied to the vascular wall, and their vascular effects were compared in streptozotocin-diabetic (STZ-D), lisinopril-administered streptozotocin-diabetic (LASTZ-D), lisinopril-administered nondiabetic (LAND), and non-diabetic (ND) groups. Vasoconstriction was induced by epinephrine in all groups in a dose-response fashion. There were statistically significant differences in maximum percent constriction between STZ-D and LASTZ-D groups. There was also a significant increase in sensitivitity to epinephrine in the STZ-D group. The vasoconstriction induced by epinephrine was relieved by chlorpromazine in all groups. Results suggest that there are important functional abnormalities in the responses of vessels to epinephrine in diabetics, and that the attenuation of vasoconstriction by ACE inhibitors may have benefical effects in microsurgical procedures performed on diabetic patients. Topically-applied chlorpromazine appears to be effective in relieving vasospasm due to epinephrine, and may be a useful tool to resolve perioperative vascular spasm in microsurgical procedures for diabetic and non-diabetic patients.en_US
dc.identifier.doi10.1055/s-2007-1000124
dc.identifier.endpage441en_US
dc.identifier.issn0743-684X
dc.identifier.issue6en_US
dc.identifier.pmid10480564en_US
dc.identifier.scopus2-s2.0-0032838777en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage439en_US
dc.identifier.urihttps://doi.org/10.1055/s-2007-1000124
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25220
dc.identifier.volume15en_US
dc.identifier.wosWOS:000082161700007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherThieme Medical Publ Incen_US
dc.relation.ispartofJournal Of Reconstructive Microsurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNorepinephrineen_US
dc.subjectReactivityen_US
dc.subjectSalvageen_US
dc.subjectDiseaseen_US
dc.subjectSpasmen_US
dc.subjectFooten_US
dc.titleVascular effects of epinephrine, lisinopril, and chlorpromazine in diabetic and non-diabetic ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu