Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Chinese Journal Cancer Research Co
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma (PAC). Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013. Results: Of 563 patients, 472 received adjuvant chemotherapy (CT) alone, chemoradiotherapy (CRT) alone, and chemoradiotherapy plus chemotherapy (CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival (RFS) and overall survival (OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant difference between groups when patients with node-negative disease or patients with or without positive surgical margins were considered. Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.
Açıklama
Anahtar Kelimeler
Pancreatic Adenocarcinoma, Adjuvant Chemotherapy (Adjuvant CT), Adjuvant Radiotherapy, Single-Institution Experience, Randomized Controlled-Trial, Seer Registry Data, Phase-Iii, Radiation-Therapy, Folinic Acid, Cancer, Chemotherapy, Radiotherapy, Gemcitabine
Kaynak
Chinese Journal Of Cancer Research
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
27
Sayı
4
