The clinical characteristics of latent autoimmune diabetes in adults and its relation with chronic complications in metabolically poor controlled Turkish patients with Type 2 diabetes mellitus

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dc.authoridSabuncu, Tevfik/0000-0001-6504-5355
dc.authorwosidSabuncu, Tevfik/ABF-5291-2020
dc.contributor.authorArikan, E
dc.contributor.authorSabuncu, T
dc.contributor.authorOzer, EM
dc.contributor.authorHatemi, H
dc.date.accessioned2024-06-12T11:16:50Z
dc.date.available2024-06-12T11:16:50Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIt has been reported that some patients with Type 2 diabetes mellitus (DM) have latent autoimmune diabetes in adults (LADA) and may show different clinical characteristics than those with Type 2 DM. We aimed to determine the ratio and clinical features of LADA in patients with diagnosed initially as Type 2 DM. We measured glutamic acid decarboxylase antibodies (GADA) in 54 patients, diagnosed clinically with Type 2 DM. Of 54 patients, 17 (31%) were GADA positive. GADA-positive patients had significantly earlier diabetes onset age (P<.001), lower BMI (P<.05), and lower serum C-peptide value (P<.001) than did those who were GADA negative. A higher proportion of the GADA-positive patients were receiving insulin therapy (P<.01). With respect to the duration of DM, familial history of DM, and the levels of blood pressures, fasting plasma glucose, and HbA1c, there was no difference between the two groups. Nephropathy and retinopathy were more frequent in GADA-positive than in GADA-negative patients. The prevalence of neuropathy was comparable between the two groups. GADA was negatively associated with BMI, C-peptide levels, and diabetes-onset age, but positively related to retinopathy, nephropathy, and insulin treatment. This study indicated that the important portion of the patients who were initially diagnosed as Type 2 DM may have LADA. In Type 2 diabetic patients who have lower BMI and diagnosis of diabetes in relatively younger age, the possibility of LADA should be taken into consideration. The higher prevalence of nephropathy and retinopathy in GADA-positive patients also suggests the importance of early diagnosis and strict metabolic control in these patients. (C) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jdiacomp.2005.02.004
dc.identifier.endpage258en_US
dc.identifier.issn1056-8727
dc.identifier.issue5en_US
dc.identifier.pmid16112499en_US
dc.identifier.scopus2-s2.0-23844516415en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage254en_US
dc.identifier.urihttps://doi.org/10.1016/j.jdiacomp.2005.02.004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24478
dc.identifier.volume19en_US
dc.identifier.wosWOS:000231871200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Diabetes And Its Complicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectGADAen_US
dc.subjectLADAen_US
dc.subjectMicrovascular Complicationsen_US
dc.subjectGlutamic-Acid Decarboxylaseen_US
dc.subjectIslet-Cellen_US
dc.subjectInsulin Requirementen_US
dc.subjectHigh Prevalenceen_US
dc.subjectNo Associationen_US
dc.subjectGad Antibodiesen_US
dc.subjectYoung-Adultsen_US
dc.subjectAutoantibodiesen_US
dc.subjectDiagnosisen_US
dc.subjectOnseten_US
dc.titleThe clinical characteristics of latent autoimmune diabetes in adults and its relation with chronic complications in metabolically poor controlled Turkish patients with Type 2 diabetes mellitusen_US
dc.typeArticleen_US

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