Clastogenicity of selective serotonin-reuptake inhibitors

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dc.authoridPalanduz, Sukru/0000-0002-9435-009X
dc.authorwosidOguz, Fatma/AAD-2962-2020
dc.authorwosidBozkurt, Gulcin/A-7599-2018
dc.authorwosidPalanduz, Sukru/AAC-6863-2020
dc.contributor.authorBozkurt, G
dc.contributor.authorAbay, E
dc.contributor.authorAtes, I
dc.contributor.authorKarabogaz, G
dc.contributor.authorTure, M
dc.contributor.authorSavran, FO
dc.contributor.authorPalanduz, S
dc.date.accessioned2024-06-12T10:56:23Z
dc.date.available2024-06-12T10:56:23Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Selective serotonin-reuptake inhibitors (SSRIs) are used in the treatment of various forms of psychiatric disorders. Preclinical studies in laboratory animals have indicated that SSRIs were not genotoxic, but clear results from in vitro testing of SSRIs in a human cell system are currently scarce. The purpose of this study was to investigate whether SSRIs might be genotoxic. Sertraline was chosen as model SSRI, since it appears to be at least as well-tolerated as other SSRIs and may even have a more favourable side-effect profile. Unlike fluoxetine, fluvoxamine and paroxetine, sertraline has low potential for pharmacokinetic drug interactions. So, sertraline would be considered first in the treatment of psychiatric disorders requiring SSRI therapy in the future. We therefore examined peripheral lymphocytes from sertraline-treated patients for both sister chromatid exchanges (SCEs), cells with a high frequency of SCEs (HFC) and chromosome aberrations (CA) to evaluate the elastogenicity of SSRIs. Method: Ten sertraline-treated patients meeting 'Structured Clinical Interview for DSM-IV' criteria for both generalized anxiety disorder and major depression were compared with 18 healthy volunteers and 18 non-treated patients with similar psychopathology. Sertraline hydrochloride was administered orally at 50 mg daily for 10 months to I year. The participants were selected on the basis of similar responses to a questionnaire assessing risk of genotoxicity related to other aspects of life. All participants had very similar lifestyles, medical histories, biological and dietary factors. All subjects were non-smokers. Result: A statistically significant difference between patients with both generalized anxiety disorder and major depression (sertraline-treated or non-treated) and healthy volunteer groups was found by both SCE frequencies and HFC percentages. Both patient groups showed higher frequencies of SCEs than the healthy controls. No statistically significant difference was found between SCE frequencies or HFC percentages observed in sertraline-treated and non-treated patient groups. No statistical difference was found between groups with respect to the frequency of CA. Conclusion: There are no adequate studies analysing the clastogenicity of SSRIs, in particular of sertraline. The SCE frequency, the percentage HFC and the frequency of CA in patients with both generalized anxiety disorder and major depression exposed to daily doses of sertraline do not indicate a possible clastogenic hazard. The increased SCE frequencies in patients with both generalized anxiety disorder and major depression in our study-irrespective of sertraline treatment-indicate a possible genotoxic effect. However, our observations were based on a limited number of patients; the results may be explained by psychogenic stress. (C) 2003 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.mrgentox.2003.11.005
dc.identifier.endpage144en_US
dc.identifier.issn1383-5718
dc.identifier.issn1879-3592
dc.identifier.issue1-2en_US
dc.identifier.pmid15036127en_US
dc.identifier.scopus2-s2.0-1242317082en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1016/j.mrgentox.2003.11.005
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19777
dc.identifier.volume558en_US
dc.identifier.wosWOS:000220006800015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMutation Research-Genetic Toxicology And Environmental Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChromosome Aberrationen_US
dc.subjectSelective Serotonin-Reuptake Inhibitorsen_US
dc.subjectSertralineen_US
dc.subjectIndicator For Detecting Clastogenicityen_US
dc.subjectSister Chromatid Exchangesen_US
dc.subjectCells With High-Frequency Sister Chromatid Exchanges (HFC)en_US
dc.subjectSister-Chromatid Exchangeen_US
dc.subjectOccupational Exposureen_US
dc.subjectDopamine Transporteren_US
dc.subjectBlood-Lymphocytesen_US
dc.subjectDna-Damageen_US
dc.subjectChromosomeen_US
dc.subjectFrequencyen_US
dc.subjectCellsen_US
dc.subjectRecombinationen_US
dc.subjectMutagenicityen_US
dc.titleClastogenicity of selective serotonin-reuptake inhibitorsen_US
dc.typeArticleen_US

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