Melatonin reduces nitric oxide via increasing arginase in rhabdomyolysis-induced acute renal failure in rats

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dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorErbas, Hakan
dc.contributor.authorAtmaca, Gulizar
dc.contributor.authorErten, Oya
dc.contributor.authorKaymak, Kadir
dc.date.accessioned2024-06-12T11:08:14Z
dc.date.available2024-06-12T11:08:14Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMelatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger. In addition to a direct scavenging effect on nitric oxide (NO), its inhibitory effect on nitric oxide synthase (NOS) activity has been also reported. L-arginine is the substrate for both NOS and arginase. It has been suggested that there is a competition between arginase and NOS and that they control each other's level. NO plays a crucial role in the pathogenesis of myoglobinuric acute renal failure (ARF). In this study, the authors aimed to investigate the effect of melatonin on arginase activity, ornithine, and NO levels on the myoglobinuric ARF formed by intramuscular (im) injection of hypertonic glycerol. Forty rats were randomly divided into four groups. Rats in SHAM were given saline, and those in groups ARF, ARF-M5, and ARF-M10 were injected with glycerol (10 mL/kg) im. Concomitant and 24 hours after glycerol injection for the ARF-M5 and ARF-M10 groups, melatonin-5 mg/kg and 10 mg/kg, respectively-was administrated intraperitoneally. Forty-eight hours after the glycerol injection, kidneys of the rats were taken under anesthesia. Arginase activity, ornithine, and NO levels in the kidney tissue were determined. Melatonin had an increasing effect on kidney tissue arginase activities and ornithine levels while decreasing NO concentration. It is possible that besides the direct scavenging effect, the stimulatory effect of melatonin on arginase activity may result in an inhibition of NOS activity and, finally, a decrease in the kidney NO level.en_US
dc.identifier.doi10.1080/08860220600683631
dc.identifier.endpage440en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue5en_US
dc.identifier.pmid16825094en_US
dc.identifier.scopus2-s2.0-33745887759en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://doi.org/10.1080/08860220600683631
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22358
dc.identifier.volume28en_US
dc.identifier.wosWOS:000238915700010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectArginaseen_US
dc.subjectOrnithineen_US
dc.subjectNitric Oxideen_US
dc.subjectMyogloxbinuric Acute Renal Failureen_US
dc.subjectL-Arginineen_US
dc.subjectSynthase Inhibitorsen_US
dc.subjectMetabolismen_US
dc.titleMelatonin reduces nitric oxide via increasing arginase in rhabdomyolysis-induced acute renal failure in ratsen_US
dc.typeArticleen_US

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