Challenges in defining radiation pneumonitis in patients with lung cancer

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dc.authoridZhou, Su-Min/0000-0002-7517-9653
dc.contributor.authorKocak, Z
dc.contributor.authorEvans, ES
dc.contributor.authorZhou, SM
dc.contributor.authorMiller, KL
dc.contributor.authorFolz, RJ
dc.contributor.authorShafman, TD
dc.contributor.authorMarks, LB
dc.date.accessioned2024-06-12T10:58:21Z
dc.date.available2024-06-12T10:58:21Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description53rd International Congress of the European-Society-for-Cardiovascular-Surgery -- JUN 02-05, 2004 -- Ljubljana, SLOVENIAen_US
dc.description.abstractPurpose: To assess the difficulty of assigning a definitive clinical diagnosis of radiation (RT)-induced lung injury in patients irradiated for lung cancer. Methods: Between 1991 and 2003, 318 patients were enrolled in a prospective study to evaluate RT-induced lung injury. Only patients with lung cancer who had a longer than 6-month follow-up (251 patients) were considered in the current analysis. Of these, 47 of 251 patients had Grade >= 2 (treated with steroids) increasing shortness of breath after RT, thought possibly consistent with pneumonitis/fibrosis. The treating physician, and one to three additional reviewing physicians, evaluated the patients or their medical records, or both. The presence or absence of confounding clinical factors that made the diagnosis of RT-induced uncertain lung injury were recorded. Results: Thirty-one of 47 patients (66%) with shortness of breath had classic pneumonitis, i.e., they responded to steroids and had a definitive diagnosis of pneumonitis. In 13 of 47 patients (28%), the diagnosis of RT-induced toxicity was confounded by possible infection; exacerbation of preexisting lung disease (chronic obstructive pulmonary disease); tumor regrowth/progression; and cardiac disease in 6, 8, 5, and 1 patients, respectively (some of the patients had multiple confounding factors and were counted more than once). An additional 3 patients (6%) had progressive shortness of breath and an overall clinical course more consistent with fibrosis. All 3 had evidence of bronchial stenosis by bronchoscopy. Conclusions: Scoring of radiation pneumonitis was challenging in 28% of patients treated for lung cancer owing to confounding medical conditions. Recognition of this uncertainty is needed and may limit our ability to understand RT-induced lung injury. (c) 2005 Elsevier Inc.en_US
dc.description.sponsorshipEuropean Soc Cardiovasc Surgen_US
dc.description.sponsorshipNCI NIH HHS [R01 CA69579] Funding Source: Medlineen_US
dc.identifier.doi10.1016/j.ijrobp.2004.12.023
dc.identifier.endpage638en_US
dc.identifier.issn0360-3016
dc.identifier.issn1879-355X
dc.identifier.issue3en_US
dc.identifier.pmid15936538en_US
dc.identifier.scopus2-s2.0-20344396842en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage635en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijrobp.2004.12.023
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20030
dc.identifier.volume62en_US
dc.identifier.wosWOS:000229766300004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofInternational Journal Of Radiation Oncology Biology Physicsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConfounding Factorsen_US
dc.subjectLung Canceren_US
dc.subjectRadiation Pneumonitisen_US
dc.subjectDose-Volume Histogramen_US
dc.subjectInjuryen_US
dc.subjectPredictorsen_US
dc.subjectRisken_US
dc.subjectComplicationsen_US
dc.subjectParametersen_US
dc.titleChallenges in defining radiation pneumonitis in patients with lung canceren_US
dc.typeConference Objecten_US

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