Carnitine or dimethyl sulfoxide, or both, for the treatment of anthracycline extravasation in rats

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dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authorwosidErdogan, Bulent/AAA-9781-2021
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.authorwosidIbis, Kamuran/AAD-1939-2019
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.authorwosidCicin, Irfan/AAQ-5575-2020
dc.contributor.authorUzunoglu, Sernaz
dc.contributor.authorCosar, Rusen
dc.contributor.authorCicin, Irfan
dc.contributor.authorIbis, Kamuran
dc.contributor.authorDemiralay, Ebru
dc.contributor.authorBenlier, Erol
dc.contributor.authorErdogan, Bulent
dc.date.accessioned2024-06-12T10:59:38Z
dc.date.available2024-06-12T10:59:38Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study aimed to compare the efficacy of topical dimethyl sulfoxide (DMSO), intralesional and systemic carnitine as monotherapy and in combination against ulceration in rats induced by intradermal doxorubicin extravasation. Sixty-nine 3-month-old male Wistar albino rats, weighing between 200-225 g, were used in this study. Rats were applied monotherapy or a combination of topical DMSO, intraperitoneal or intralesional carnitine. Control groups received saline or no drug. The necrotic area was measured and extravasated neutrophil leukocytes were counted in healthy tissue adjacent to necrotic areas. Monotherapy with topical and systemic carnitine did not significantly reduce the size of necrotic areas. However, topical DMSO had reduced necrotic areas and inflammatory cells significantly and the addition of systemic carnitine to topical DMSO had increased the efficacy. DMSO is an effective, safe, and easy-to-apply treatment for doxorubicin-induced extravasation. Further clinical studies are needed to evaluate the use of carnitine in combination with DMSO.en_US
dc.identifier.doi10.3109/2000656X.2013.767201
dc.identifier.endpage343en_US
dc.identifier.issn2000-656X
dc.identifier.issue5en_US
dc.identifier.pmid23710793en_US
dc.identifier.scopus2-s2.0-84884230160en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage339en_US
dc.identifier.urihttps://doi.org/10.3109/2000656X.2013.767201
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20506
dc.identifier.volume47en_US
dc.identifier.wosWOS:000324533400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofJournal Of Plastic Surgery And Hand Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDimethyl Sulfoxideen_US
dc.subjectCarnitineen_US
dc.subjectExtravasationen_US
dc.subjectHyperbaric-Oxygen Therapyen_US
dc.subjectAdriamycin Extravasationen_US
dc.subjectSkin Necrosisen_US
dc.subjectTopical Dimethylsulfoxideen_US
dc.subjectDoxorubicinen_US
dc.subjectPreventionen_US
dc.subjectInjuryen_US
dc.subjectDexrazoxaneen_US
dc.subjectUlcerationen_US
dc.subjectDmsoen_US
dc.titleCarnitine or dimethyl sulfoxide, or both, for the treatment of anthracycline extravasation in ratsen_US
dc.typeArticleen_US

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