SURVIVIN POSITIVITY AND PROGNOSTIC FACTORS IN PAPILLARY THYROID CARCINOMAS

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dc.authoridyılmaz bülbül, buket/0000-0003-2651-0036
dc.authoridAytürk Salt, Semra/0000-0002-1560-3459
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authorwosidPuyan, Fulya Oz/A-7804-2016
dc.authorwosidyılmaz bülbül, buket/JVZ-4676-2024
dc.authorwosidAytürk Salt, Semra/U-4265-2017
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.contributor.authorKeskin, E. Usturali
dc.contributor.authorTastekin, E.
dc.contributor.authorCan, N.
dc.contributor.authorMut, A. N.
dc.contributor.authorCelik, M.
dc.contributor.authorBulbul, B. Yilmaz
dc.contributor.authorPuyan, F. Oz
dc.date.accessioned2024-06-12T11:12:02Z
dc.date.available2024-06-12T11:12:02Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractContext. Papillary thyroid carcinoma(PTC)s are the indolent progressive tumours. Survivin is a unique bifunctional protein with cell cycle regulation and apoptosis inhibition. The expression of this protein has been shown to be increased in thyroid tumours correlated with aggressive behavior from well differentiated to anaplastic. Objective. In this study, we aimed to investigate the relationship between immunohistochemically survivin expression and tumour-associated prognostic factors in papillary thyroid carcinomas. Design. In patients with thyroidectomy, we compared the clinicopathological findings and immunohistochemical positivity for survivin. Subjects and Methods. In 109 patients, sex, age, tumour size, histological tumour variant, tumour focality, tumour border pattern, tumour peripheral/intratumoural lymphocytic and stromal response, intraglandular spread, extrathyroideal spread, lymph node metastases, lymphocytic tiroiditis and relationships of these findings with survivin positivity were investigated. Results. When we indicated the tumour size and compared it with survivin expression, tumour size correlates with, survivin expression (p = 0.016). Survivin expression was correlated statistically significant with lymphovascular invasion, without stromal response and with intraglandular extension respectively (p<0.001, p = 0.043, p<0.001). No significant correlation was found between other clinicopathological parameters and survival. Conclusion. Few studies have investigated the relationship of survivin expression with prognosis in thyroid papillary carcinomas and showed that survivin was a poor prognostic marker. If its expression is detected in preoperative cytology smears, it may affects the surgical treatment strategy. When it is detected in the tissue, postoperative radioactive iodine treatment plan may be modified and the need for more aggressive follow-up may be considered.en_US
dc.identifier.doi10.4183/aeb.2021.455
dc.identifier.endpage461en_US
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.issue4en_US
dc.identifier.pmid35747869en_US
dc.identifier.scopus2-s2.0-85135328295en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage455en_US
dc.identifier.urihttps://doi.org/10.4183/aeb.2021.455
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23017
dc.identifier.volume17en_US
dc.identifier.wosWOS:000810534800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofActa Endocrinologica-Bucharesten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPapillary Thyroid Carcinomaen_US
dc.subjectSurvivinen_US
dc.subjectThyroiden_US
dc.subjectGene Polymorphismen_US
dc.subjectAssociationen_US
dc.subjectExpressionen_US
dc.subjectGrowthen_US
dc.subjectSystemen_US
dc.titleSURVIVIN POSITIVITY AND PROGNOSTIC FACTORS IN PAPILLARY THYROID CARCINOMASen_US
dc.typeArticleen_US

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