Low leptin levels in migraine: A case control study

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dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.contributor.authorGuldiken, Baburhan
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorTurgut, Nilda
dc.contributor.authorTugrul, Armagan
dc.date.accessioned2024-06-12T11:07:37Z
dc.date.available2024-06-12T11:07:37Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground.-Obesity has been shown to be a risk factor for transformation of episodic migraine to chronic form, and adipocytokines have been implicated to modulate some of the cytokins such as interleukin-6 and tumor necrosis factor, which also act in the neurogenic inflammation in migraine. The aim of the study was to assess leptin levels, one of the adipocytokines, in headache-free period of migraine patients and investigate its relation to vascular risk factors. Material and Methods.-Sixty-one patients with episodic migraine headaches and 64 control subjects were enrolled in the study. Demographic data and anthropometric measurements were obtained from all participants; body mass index and fat mass values were calculated. Glucose and lipid parameters were measured by oxidase technique and cholesterol esterase enzymatic assays, and leptin levels were measured by ELISA in serum samples obtained after an overnight fasting. Results.-Leptin levels were found significantly lower in migraineurs than controls (40.1 +/- 21.2 ng/mL, 48.5 +/- 24.5 ng/mL; P < .05). Although body mass index did not differ between 2 groups, fat mass, and fat percentages were significantly lower in migraine patients (19.4 +/- 8.8 kg, 26.0 +/- 8.7 kg; P < .001 and 28 +/- 9%, 34 +/- 5%; P < .001, respectively). Conclusion.-Migraine patients have low leptin levels and fat mass which may be related to the pathogenesis of migraine. The importance and impact of our findings on the prevalence, characteristics, and treatment of migraine needs to be investigated in further detailed studies.en_US
dc.identifier.doi10.1111/j.1526-4610.2008.01152.x
dc.identifier.endpage1107en_US
dc.identifier.issn0017-8748
dc.identifier.issn1526-4610
dc.identifier.issue7en_US
dc.identifier.pmid18547265en_US
dc.identifier.scopus2-s2.0-46749107142en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1103en_US
dc.identifier.urihttps://doi.org/10.1111/j.1526-4610.2008.01152.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22109
dc.identifier.volume48en_US
dc.identifier.wosWOS:000257483200016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHeadacheen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeptinen_US
dc.subjectMigraineen_US
dc.subjectObesityen_US
dc.subjectFat Massen_US
dc.subjectBody Mass Indexen_US
dc.subjectProinflammatory Cytokinesen_US
dc.subjectSerum Leptinen_US
dc.subjectObesityen_US
dc.subjectGeneen_US
dc.subjectPlasmaen_US
dc.subjectRisken_US
dc.subjectAdiponectinen_US
dc.subjectActivationen_US
dc.subjectExpressionen_US
dc.subjectHeadacheen_US
dc.titleLow leptin levels in migraine: A case control studyen_US
dc.typeArticleen_US

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