EFFECTS OF CHADS2 SCORE, ECHOCARDIOGRAPHIC AND HAEMATOLOGIC PARAMETERS ON STROKE SEVERITY AND PROGNOSIS IN PATIENTS WITH STROKE DUE TO NONVALVULAR ATRIAL FIBRILLATION

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dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authoridAYNACI, GULDEN/0000-0002-2112-8631
dc.authorwosidKEHAYA, Sezgin/P-6106-2019
dc.authorwosidKEHAYA, Sezgin/GVU-6069-2022
dc.authorwosidKEHAYA, Sezgin/N-9995-2017
dc.contributor.authorAynaci, Ozer
dc.contributor.authorTekatas, Asian
dc.contributor.authorAynaci, Gulden
dc.contributor.authorKehaya, Sezgin
dc.contributor.authorUtku, Ufuk
dc.date.accessioned2024-06-12T10:56:07Z
dc.date.available2024-06-12T10:56:07Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction - The aim of this study is to evaluate utility of CHADS2 score to estimate stroke severity and prognosis in patients with ischemic stroke due to non-valvular atrial fibrillation (AF) in addition to evaluate effects of hematologic and echocardiographic findings on stroke severity and prognosis. Methods - This prospective study included 156 ischemic stroke cases due to non-valvular AF in neurology ward of Trakya University Medical School between March 2013-March 2015. National Institute of Health Stroke (NIHS) score was used to evaluate severity of stroke at admission. Carotid and vertebral Doppler ultrasonography findings, brain computed tomography (CT) and magnetic resonance imaging (MRI) of the cases were evaluated. Left atrial diameter and ejection fraction (EF) values were measured. CHADS2 score was calculated. Modified Rankin Scale was used to rate the degree of dependence. Effects of age and sex of the patients, presence of diabetes mellitus (DM), Congestive Heart Failure (CHF), Cerebrovascular Disease (CVD) and C-reactive protein (CRP) levels on CHADS2, NIHS, and mRS were evaluated. Results - In patients with age >= 75, mean NIHS score was 3.3 points and mean mRS score was 1.02 points higher, than in patient below 75 years of age. Compared with the mild risk group, cases in the high risk group had older age, higher serum D-dimer, fibrinogen and CRP levels and lower EF. A positive relation was detected between stroke severity and Hemorrhagic Transformation (HT), previous CVD history, and presence of CHF. A significant association was found between increased stroke severity and Early Neurological Deterioration (END) development. Older age, higher serum fibrinogen, D-dimer, CRP and lower EF values were associated with poor prognosis. History of CVD and presence of CHF were associated with poor prognosis. END development was found to be associated with poor prognosis. In the high-risk group, 30.3% (n = 33) had END. Among those in the high-risk group according to the CHADS2 score, END development rate was found to be significantly higher than in the moderate risk group (p < 0.05). There was a strong positive correlation between CHADS2 and NIHS scores. mRS score increased with increasing CHADS2 score and there was a strong correlation between them. Effect of stroke severity on prognosis was assessed and a positive correlation was found between NIHS score and mRS value. Discussion - Our study demonstrated the importance of CHADS2 score, haemostatic activation and echocardiographic findings to assess stroke severity and prognosis. Knowing factors which affect stroke severity and prognosis in patients with ischemic stroke may be directive to decide primary prevention and stroke management.en_US
dc.identifier.doi10.18071/isz.72.0241
dc.identifier.endpage250en_US
dc.identifier.issn0019-1442
dc.identifier.issn2498-6208
dc.identifier.issue7-8en_US
dc.identifier.pmid31517456en_US
dc.identifier.scopus2-s2.0-85070936565en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.18071/isz.72.0241
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19682
dc.identifier.volume72en_US
dc.identifier.wosWOS:000478703600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLiteratura Medicaen_US
dc.relation.ispartofIdeggyogyaszati Szemle-Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCHADS2 Scoreen_US
dc.subjectStroke Severityen_US
dc.subjectIschemic Strokeen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectAcute Ischemic-Strokeen_US
dc.subjectGender-Differencesen_US
dc.subjectClinical-Outcomesen_US
dc.subjectFibrinogen Levelsen_US
dc.subjectRisk-Factorsen_US
dc.subjectTerm Risken_US
dc.subjectDeathen_US
dc.subjectCha(2)Ds(2)-Vascen_US
dc.subjectHyperfibrinogenemiaen_US
dc.titleEFFECTS OF CHADS2 SCORE, ECHOCARDIOGRAPHIC AND HAEMATOLOGIC PARAMETERS ON STROKE SEVERITY AND PROGNOSIS IN PATIENTS WITH STROKE DUE TO NONVALVULAR ATRIAL FIBRILLATIONen_US
dc.typeArticleen_US

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