Antinuclear, Cytoskeletal, Antineuronal Antibodies in the Serum Samples of Children with Tic Disorders and Obsessive Compulsive Disorders

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dc.authorid, Piraye/0000-0001-8202-5313
dc.authorwosidÖmeroğlu, Rukiye Nurten/AAT-7658-2020
dc.contributor.authorGorker, Isik
dc.contributor.authorDemir, Gulsen Akman
dc.contributor.authorPolat, Nuray Gurel
dc.contributor.authorOmeroglu, Rukiye Eker
dc.contributor.authorIcoz, Sema
dc.contributor.authorSerdaroglu, Piraye
dc.contributor.authorTuzun, Umran
dc.date.accessioned2024-06-12T11:16:26Z
dc.date.available2024-06-12T11:16:26Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: As environmental factors, the role of Group A beta hemolytic streptococcus infections in the development of tic and obsessive compulsive disorders (OCD) is controversial. The autoimmune hypothesis states that during infection, formation of autoantibodies leads to an autoimmune disorder, which in turn results in movement disorders, tic disorders and/or OCD. In order to test this hypothesis, we assayed these antibodies in children and adolescents diagnosed with tic disorders and/or OCD. Material and Methods: Children and adolescents who were diagnosed with either tic disorders or OCD according to DSM-IV criteria (n=28), were compared with healthy controls (n=15) having similar age and gender characteristics. Regardless of a streptococcus infection history, serum samples of all patients and controls underwent antinuclear, cytoskeletal, and antineuronal antibody assay using indirect immunofluorescence. Results: The rates of antinuclear antibody positivity were 21% and 20% in the patient and control groups respectively (p>0.05). Antineuronal antibody was positive in 2 (7%) of 28 patients versus in 1 (6%) of 15 controls (p>0.05). Conclusion: These results suggest that such antibodies may not be involved in the pathogenesis of tic disorders/OCD.en_US
dc.identifier.doi10.5152/balkanmedj.2011.020
dc.identifier.endpage444en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-82155202986en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage440en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2011.020
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24309
dc.identifier.volume28en_US
dc.identifier.wosWOS:000297455600016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTic Disordersen_US
dc.subjectObsessive Compulsive Disorderen_US
dc.subjectPANDASen_US
dc.subjectAutoimmunityen_US
dc.subjectChilden_US
dc.subjectChoreaen_US
dc.subjectSymptomsen_US
dc.subjectNuclearen_US
dc.subjectTitersen_US
dc.subjectScaleen_US
dc.titleAntinuclear, Cytoskeletal, Antineuronal Antibodies in the Serum Samples of Children with Tic Disorders and Obsessive Compulsive Disordersen_US
dc.typeArticleen_US

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