F-18 fluoride uptake in primary breast cancer

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dc.contributor.authorSarikaya, Ismet
dc.contributor.authorSharma, Prem
dc.contributor.authorSarikaya, Ali
dc.date.accessioned2019-06-26T07:38:04Z
dc.date.available2019-06-26T07:38:04Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Anabilim Dalıen_US
dc.descriptionSarikaya, Ali (Trakya author)en_US
dc.description.abstractObjectiveBone-specific radiotracers are known to accumulate in breast lesions. Tc-99m diphosphonates have been widely studied in differentiating breast lesions. In this retrospective study, we aimed to assess the uptake of the bone-specific PET radiotracer, F-18 fluoride (NaF), in primary breast cancers to determine its sensitivity and to identify any differences in NaF uptake between calcified and non-calcified tumors, histological subtypes, and patients with or without axillary lymphadenopathy.MethodsNaF positron emission tomography/computed tomography (PET/CT) images of 69 newly diagnosed breast cancer patients were reviewed. F-18 fluoride uptake as maximum standardized uptake value (NaF SUVmax) was measured in the primary tumor, enlarged axillary lymph nodes and contralateral normal/non-tumoral breast tissue. Low-dose CT images were reviewed to locate the primary tumor and grossly assess its calcification and check for ipsilateral axillary lymphadenopathy. Whole body NaF PET/CT images were reviewed to search for bone metastases. Eighteen patients also underwent F-18 fluorodeoxyglucose (FDG) PET/CT study.ResultsThe primary breast tumor was clearly seen as focal or diffuse uptake on NaF PET images in 27 of 69 patients (39%) (mean NaF SUVmax: 2.01.0). In the rest, there was only mild bilateral diffuse breast uptake. When analyzing images per histological subtype (42 patients, 43 tumors), 14 of 31 invasive ductal carcinomas (IDC) (45%) and 3 of 4 ductal carcinoma in situ (DCIS) were visible on PET. Five invasive lobular carcinomas, 2 invasive mammary carcinomas, and 1 mucinous carcinoma were not visible on PET. Mean NaF SUVmax of contralateral normal/non-tumoral breast tissue was 1.0 +/- 0.4. There was no significant difference in mean NaF SUVmax of primary tumor in cases with and without calcification or with and without axillary lymphadenopathy (p 0.892 and 0.957). There was no correlation between NaF SUVmax and FDG SUVmax values of the primary tumors (r 0.072, p 0.797, Pearson correlation).ConclusionNaF PET has relatively low sensitivity in detecting breast cancer. However, abnormal breast uptake on NaF PET requires further evaluation. F-18 fluoride uptake in the primary breast tumor does not seem to be correlated with axillary lymphadenopathy (metastasis potential), gross tumor calcification or metabolic activity of the tumor.en_US
dc.identifier.citationSarikaya, I., Sharma, P., & Sarikaya, A. (2018). F-18 fluoride uptake in primary breast cancer. Annals of nuclear medicine, 32(10), 678-686.en_US
dc.identifier.doi10.1007/s12149-018-1294-4en_US
dc.identifier.endpage686en_US
dc.identifier.issue10en_US
dc.identifier.pmid30178199en_US
dc.identifier.scopus2-s2.0-85053387955en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage678en_US
dc.identifier.urihttps://doi.org/10.1007/s12149-018-1294-4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/4239
dc.identifier.volume32en_US
dc.identifier.wosWOS:000449929600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectBreast Canceren_US
dc.subjectPrimary Breast Tumoren_US
dc.subjectPETen_US
dc.subjectCTen_US
dc.subjectF-18 Fluorideen_US
dc.subjectNaFen_US
dc.subjectDiphosphonate Scintimammographyen_US
dc.subjectTc-99m Mdpen_US
dc.subjectMicrocalcificationsen_US
dc.subjectCarcinomaen_US
dc.subjectCalcificationsen_US
dc.subjectScintigraphyen_US
dc.subjectMechanismen_US
dc.subjectFeaturesen_US
dc.subjectLesionsen_US
dc.subjectWomenen_US
dc.titleF-18 fluoride uptake in primary breast canceren_US
dc.typeArticleen_US

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