The impact of pre-radiotherapy surgery on radiation-induced lung injury

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dc.authoridZhou, Su-Min/0000-0002-7517-9653
dc.contributor.authorKocak, Z
dc.contributor.authorYu, X
dc.contributor.authorZhou, SM
dc.contributor.authorD'Amico, TA
dc.contributor.authorHollis, D
dc.contributor.authorKahn, D
dc.contributor.authorTisch, A
dc.date.accessioned2024-06-12T11:07:54Z
dc.date.available2024-06-12T11:07:54Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description40th Annual Meeting of the American-Society-of-Clinical-Oncology -- JUN 05-08, 2004 -- New Orleans, LAen_US
dc.description.abstractAims: The use of postoperative radiation therapy (PORT) is predicated by an assessment of the potential benefits and risks, including radiation-induced lung injury. In this study, the risk of radiation-induced lung injury is assessed in patients who received PORT, and compared with a group of patients who received radiation without prior surgery, to determine if surgery increases the risk of radiation pneumonitis. Materials and methods: From 1991 to 2003, 251 patients with lung cancer were enrolled into a prospective study to assess radiation-induced lung injury. All patients received three-dimensional-planned, external-beam radiotherapy. One hundred and seventy-seven patients with over 6-months follow-up were eligible. For the current analysis, 49 patients (28%) had surgical intervention before radiotherapy. The rates of Grade 2 symptomatic pneumonitis in subgroups, based on the type of pre-radiation surgery, were computed and compared using Fisher's Exact Test. To consider the confounding factor of irradiated lung volume, patient subgroups were further defined on the basis of the mean lung dose. Results: Surgical procedures included pneumonectomy (n = 9), lobectomy (n = 16), wedge resection (n = 8) and exploration without resection (n = 16). Radiation-induced lung injury occurred in 33 out of 177 (19%) patients, including 18% of the surgical group and 19% of the non-surgical group. Additionally, no statistically significant difference was found in the rate of radiation-induced lung injury based on the extent of resection. Conclusions: The incidence of pneumonitis is similar in the surgical and non-surgical groups. Thus, PORT may be safely given to selected patients after surgical exploration or resection. (c) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipAmer Soc Clin Oncolen_US
dc.description.sponsorshipNCI NIH HHS [R01 CA69579] Funding Source: Medlineen_US
dc.identifier.doi10.1016/j.clon.2004.11.013
dc.identifier.endpage216en_US
dc.identifier.issn0936-6555
dc.identifier.issn1433-2981
dc.identifier.issue4en_US
dc.identifier.pmid15999420en_US
dc.identifier.scopus2-s2.0-19144366651en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage210en_US
dc.identifier.urihttps://doi.org/10.1016/j.clon.2004.11.013
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22230
dc.identifier.volume17en_US
dc.identifier.wosWOS:000229824100002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Londonen_US
dc.relation.ispartofClinical Oncologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLung Canceren_US
dc.subjectRadiotherapyen_US
dc.subjectRadiation Pneumonitisen_US
dc.subjectSurgeryen_US
dc.subjectVolume Histogram Analysisen_US
dc.subjectPostoperative Radiotherapyen_US
dc.subjectCancer Patientsen_US
dc.subjectRisk-Factorsen_US
dc.subjectPneumonitisen_US
dc.subjectIrradiationen_US
dc.subjectResectionen_US
dc.subjectTherapyen_US
dc.subjectStageen_US
dc.titleThe impact of pre-radiotherapy surgery on radiation-induced lung injuryen_US
dc.typeConference Objecten_US

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