Understanding the role of vitamin A and its precursors in the immune system

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dc.authoridAKTAÇ, ŞULE/0000-0002-2158-5015
dc.authoridGürbüz, Murat/0000-0001-7778-7524;
dc.authorwosidAKTAÇ, ŞULE/AAD-3809-2019
dc.authorwosidGürbüz, Murat/ACQ-8389-2022
dc.authorwosid/ABU-2133-2022
dc.contributor.authorGurbuz, Murat
dc.contributor.authorAktac, Sule
dc.date.accessioned2024-06-12T11:13:37Z
dc.date.available2024-06-12T11:13:37Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractVitamin A is the first defined vitamin and is also known as an anti-inflammatory micronutrient. Although the primary biological function is preservation of epithelial tissue integrity, vision and growth, vitamin A also plays a role in immune system regulation. It is known that susceptibility to infections increases in developing countries due to vitamin A deficiency. Therefore, the purpose of this review is to evaluate the role of vitamin A on the immune system in line with current studies. In this review, we focused on the immunobiological effects of vitamin A and its precursors. Vitamin A refers to retinoids and carotenoids, but both function in the body through the most active form, all trans retinoic acid. All trans retinoic acid has the highest affinity of nuclear retinoic acid receptor. Reports from in-vivo and in-vitro studies shown that the formation of retinoic acid/retinoic acid receptor complex is important in the generation of innate and adaptive immune cell response. In addition to immune cell response, vitamin A also plays an important role in mucus secretion, morphological formation and functional maturation of epithelial cells. In this way, vitamin A appears to contribute to immune development by regulating immune cell response and providing mechanistic defense. Vitamin A has received particular attention in recent years as the vitamin have been shown to have a crucial effect on the immune response. Although more randomized controlled studies are needed, data from observational human studies have shown that vitamin A is associated with infectious, inflammatory, allergic diseases and cancers. ?? 2021 Published by Elsevier Masson SAS on behalf of Soci??t?? francophone nutrition clinique et m??tabolisme (SFNCM).en_US
dc.identifier.doi10.1016/j.nupar.2021.10.002
dc.identifier.endpage98en_US
dc.identifier.issn0985-0562
dc.identifier.issn1768-3092
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85125891291en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1016/j.nupar.2021.10.002
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23618
dc.identifier.volume36en_US
dc.identifier.wosWOS:000817753200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMasson Editeuren_US
dc.relation.ispartofNutrition Clinique Et Metabolismeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRetinolen_US
dc.subjectRetinoic Aciden_US
dc.subjectCarotenoiden_US
dc.subjectImmune Systemen_US
dc.subjectTrans-Retinoic Aciden_US
dc.subjectIntestinal Epithelial-Cellsen_US
dc.subjectInnate Lymphoid-Cellsen_US
dc.subjectTretinoin 0.05-Percent Lotionen_US
dc.subjectSevere Acne-Vulgarisen_US
dc.subjectOnce-Daily Treatmenten_US
dc.subjectRegulatory T-Cellsen_US
dc.subjectRat-Liveren_US
dc.subjectInterferon-Gammaen_US
dc.subjectGene-Expressionen_US
dc.titleUnderstanding the role of vitamin A and its precursors in the immune systemen_US
dc.typeArticleen_US

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