Evaluation of pulmonary alveolo-capillary permeability in Type 2 diabetes mellitus using technetium 99mTc-DTPA aerosol scintigraphy and carbon monoxide diffusion capacity

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dc.authoridOzkan, Zeynep Gozde/0000-0003-0360-358X
dc.authorwosidOzkan, Zeynep Gozde/AAT-7966-2020
dc.contributor.authorOzsahin, Kemal
dc.contributor.authorTugrul, Armagan
dc.contributor.authorMert, Selva
dc.contributor.authorYuksel, Mahmut
dc.contributor.authorTugrul, Gozde
dc.date.accessioned2024-06-12T10:59:24Z
dc.date.available2024-06-12T10:59:24Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe thickening of alveolar basement membrane is found in autopsies, along with microvascular pathologies, in Type I and 2 diabetes mellitus (DM). To detect the function and permeability of alveolar basement membrane, carbon monoxide diffusion capacity (DLCO) and technetium 99m-diethyltriaminepentaaceticacid (Tc-99m-DTPA) aerosol scintigraphy methods can be used. The aim of this study was to determine alveolar basement membrane damage using these two methods. Nineteen women and 6 men, nonsmoking, Type 2 DM cases, without any lung and/or heart disease and who had neither anemia nor obesity, made up the patient group. They were compared with six female and nine male healthy cases who had the same characteristics with the diabetes cases. All of the cases DLCO were measured by single-breath method and 99mTc-DTPA aerosol scintigraphy was performed. DLCO showed no difference between the two groups. Aerosol scintigraphy was significantly decreased in the diabetic group (P=.01). In cases with > 5 years of diabetic duration (P <.01), in cases with glycolized hemoglobin (HbA(1c)) <= 8% (P <.05) and > 8% (P <.05), and in microangiopathic cases (P <.01), alveolo-capillary permeability was significantly decreased than in the control group. Among the same groups, no significant difference could be detected for DLCO. The permeability of alveolar basement membrane can reduce in respect to diabetes duration and poor metabolic control. According to our investigation, Tc-99m-DTPA aerosol scintigraphy method is more sensitive than DLCO method for determining these pathologies. (c) 2006 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jdiacomp.2005.07.003
dc.identifier.endpage209en_US
dc.identifier.issn1056-8727
dc.identifier.issue4en_US
dc.identifier.pmid16798470en_US
dc.identifier.scopus2-s2.0-33746968159en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://doi.org/10.1016/j.jdiacomp.2005.07.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20433
dc.identifier.volume20en_US
dc.identifier.wosWOS:000239080900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Diabetes And Its Complicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectAlveolar Basement Membraneen_US
dc.subjectMicroangiopathyen_US
dc.subjectAerosol Scintigraphyen_US
dc.subjectPulmonary Function Testsen_US
dc.subjectGas-Exchangeen_US
dc.subjectLungen_US
dc.subjectJointen_US
dc.titleEvaluation of pulmonary alveolo-capillary permeability in Type 2 diabetes mellitus using technetium 99mTc-DTPA aerosol scintigraphy and carbon monoxide diffusion capacityen_US
dc.typeArticleen_US

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