Ignored Role of Paroxysmal Atrial Fibrillation in the Pathophysiology of Cryptogenic Stroke in Patients with Patent Foramen Ovale and Atrial Septal Aneurysm

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dc.contributor.authorYetkin, Ertan
dc.contributor.authorAtmaca, Hasan
dc.contributor.authorCuglan, Bilal
dc.contributor.authorYalta, Kenan
dc.date.accessioned2024-06-12T11:15:42Z
dc.date.available2024-06-12T11:15:42Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe association between cryptogenic stroke (CS) and patent foramen ovale (PFO) with or without atrial septal aneurysm (ASA) has been a debate for decades in terms of pathophysiologic processes and clinical courses. This issue has become more interesting and complex, because of the concerns associating the CS with so-called normal variant pathologies of interatrial septum, namely ASA and PFO. While there is an anatomical pathology in the interatrial septum, namely PFO and ASA, the embolic source of stroke is not clearly defined. Moreover, in patients with PFO and CS, the risk of recurrent stroke has also been associated with other PFO-unrelated factors, such as hyperlipidemia, body mass index, diabetes mellitus, and hypertension, leading to the difficulty in understanding the pathophysiologic mechanism of CS in patients with PFO and/or ASA. Theoretically, the embolic source of cryptogenic stroke in which PFO and/or ASA has been involved can be categorized into three different anatomical locations, namely PFO tissue and/or ASA tissue itself, right or left atrial chambers, and venous vascular territory distal to the right atrium, i.e., inferior vena cava and lower extremity venous system. However, the possible role of paroxysmal atrial fibrillation associated with PFO and/or ASA as a source of cryptogenic stroke has never been mentioned clearly in the literature. This review aims to explain the association of cryptogenic stroke with PFO and/or ASA in a comprehensive manner, including anatomical, clinical, and mechanistic aspects.The potential role of paroxysmal atrial fibrillation and its contribution to clinical course have been also discussed in a hypothetical manner to elucidate the pathophysiology of CS and support further treatment modalities.en_US
dc.identifier.doi10.2174/011573403X267669240125041203
dc.identifier.issn1573-403X
dc.identifier.issn1875-6557
dc.identifier.issue2en_US
dc.identifier.pmid38367262en_US
dc.identifier.scopus2-s2.0-85191896955en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.2174/011573403X267669240125041203
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24036
dc.identifier.volume20en_US
dc.identifier.wosWOS:001169757900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Cardiology Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStrokeen_US
dc.subjectCryptogenic Strokeen_US
dc.subjectAtrial Septal Aneurysmen_US
dc.subjectPatent Foramen Ovaleen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectPathophysiologyen_US
dc.subjectUndetermined Sourceen_US
dc.subjectMedical Therapyen_US
dc.subjectEmbolic Strokeen_US
dc.subjectClosureen_US
dc.subjectRisken_US
dc.subjectPrevalenceen_US
dc.subjectSizeen_US
dc.titleIgnored Role of Paroxysmal Atrial Fibrillation in the Pathophysiology of Cryptogenic Stroke in Patients with Patent Foramen Ovale and Atrial Septal Aneurysmen_US
dc.typeReview Articleen_US

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