Sesamin ameliorates mucosal tissue injury of mesenteric ischemia and reperfusion in an experimental rat model

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dc.authoridSALT, OMER/0000-0002-5557-6627
dc.authorwosidCan, Nuray/D-3452-2016
dc.authorwosidOguz, Serhat/HKE-2793-2023
dc.contributor.authorSayhan, Mustafa B.
dc.contributor.authorOguz, Serhat
dc.contributor.authorSalt, Omer
dc.contributor.authorCan, Nuray
dc.contributor.authorOzgurtas, Taner
dc.contributor.authorYalta, Tulin D.
dc.date.accessioned2024-06-12T11:08:23Z
dc.date.available2024-06-12T11:08:23Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: Mesenteric ischemia/reperfusion (I/R) injury is a serious clinical condition. There were a lot of experimental studies performed in the treatment of I/R injury. To our knowledge, this is the first experimental study with effects of sesamin on I/R injury model. We aimed to investigate the protective effect of sesamin on mesenteric I/R injury model. Material and methods: A total of 32 male Sprague-Dawley rats were divided into four groups. Control group: superior mesenteric artery (SMA) exposed without clamping. I/R group: SMA was clamped for 60 min and then reperfused for 2 h. Sesamin group (S): 30 mg/kg sesamin were given for 5 days, and SMA exposed without clamping. I/R + S group: 30 mg/kg sesamin were given for 5 days, SMA was clamped for 60 min, and then reperfused for 2 h. Plasma and tissue oxidant parameters were investigated as well as histopathological evaluation. Results: Plasma and tissue total antioxidant status (TAS) levels were significantly higher in I/R + S group compared to the rest (p < 0.005). The plasma TAS levels in I/R group was significantly low. The highest tissue TAS levels were detected in I/R + S group. The high levels of plasma and tissue TOS were found in I/R + S group. Plasma and tissue OSI levels were significantly higher in I/R group. Histopathologic evaluation showed that the mean level of intestinal tissue injury score in I/R group was 2.75 and 1.38 in I/R + S group. Conclusions: Sesamin helps to protect the intestinal tissue at the cellular level by reducing the oxidative stress and inflammation at both the plasma and tissue levels in the experimental I/R model.en_US
dc.identifier.doi10.5114/aoms.2017.68535
dc.identifier.endpage1588en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue6en_US
dc.identifier.pmid31749888en_US
dc.identifier.scopus2-s2.0-85074971819en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1582en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2017.68535
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22399
dc.identifier.volume15en_US
dc.identifier.wosWOS:000494945800027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMesenteric Ischemia Reperfusionen_US
dc.subjectSesaminen_US
dc.subjectOxidant Parametersen_US
dc.subjectRaten_US
dc.subjectUp-Regulationen_US
dc.subjectIntestinal Ischemiaen_US
dc.subjectOxidative Stressen_US
dc.subjectDysfunctionen_US
dc.subjectApoptosisen_US
dc.subjectProtectsen_US
dc.subjectDamageen_US
dc.titleSesamin ameliorates mucosal tissue injury of mesenteric ischemia and reperfusion in an experimental rat modelen_US
dc.typeArticleen_US

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