Association of simple hematological parameters with disease manifestations, activity, and severity in patients with systemic sclerosis

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dc.authoridTorgutalp, Murat/0000-0003-4600-9484
dc.authoridAtes, Askin/0000-0003-1966-3333
dc.authoridKINIKLI, GÜLAY/0000-0002-4006-1022
dc.authoridSezer, Serdar/0000-0001-5401-5599
dc.authoridTurgay, Murat/0000-0001-5302-4485
dc.authoridIlgen, Ufuk/0000-0001-6443-6426
dc.authoridYayla, Mucteba Enes/0000-0002-5998-6703
dc.authorwosidilgen, ufuk/R-8761-2017
dc.authorwosidTorgutalp, Murat/ABA-3372-2021
dc.authorwosidTorgutalp, Murat/GXG-6984-2022
dc.authorwosidAteş, Aşkın/HJI-6996-2023
dc.authorwosidAtes, Askin/AAG-7996-2020
dc.authorwosidKINIKLI, GÜLAY/AAP-7957-2020
dc.authorwosidSezer, Serdar/AAY-6610-2021
dc.contributor.authorYayla, Mucteba Enes
dc.contributor.authorIlgen, Ufuk
dc.contributor.authorOkatan, Ilyas Ercan
dc.contributor.authorUsluYurteri, Emine
dc.contributor.authorTorgutalp, Murat
dc.contributor.authorKelesoglu Dincer, Ayse Bahar
dc.contributor.authorAydemir Guloksuz, Emine Gozde
dc.date.accessioned2024-06-12T10:58:12Z
dc.date.available2024-06-12T10:58:12Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction/objectives Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), mean platelet volume (MPV), and red cell distribution width (RDW) may potentially reflect inflammatory status in systemic autoimmune diseases. The aim of this study is to investigate the association between these proposed markers and disease manifestations, activity, and severity in systemic sclerosis (SSc). Method We conducted a cross-sectional study of 69 systemic sclerosis (SSc) patients and 50 healthy volunteers in a single center. Adult patients with SSc and healthy controls were compared in terms of NLR, MLR, MPV, RDW, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Venous blood samples were drawn after at least 8 h of fasting in the morning. Extension of skin fibrosis was evaluated by using modified Rodnan skin score (mRSS). Disease severity and activity were assessed by Medsger disease severity and European Scleroderma Trials and Research Group (EUSTAR) disease activity scores, respectively. Associations of disease manifestations, clinical, laboratory, and capillaroscopic findings, mRSS, and the disease activity and severity scores with the proposed hematological markers were evaluated. Multiple regression models were generated for significant associations. Results The neutrophil number was higher (p = 0.004) and lymphocyte number was lower (p < 0.001) in SSc group compared to controls. SSc group also had higher NLR, MLR, and RDW. In multiple logistic regression, only the NLR (regression coefficient = 3.49, p = 0.031) and CRP (regression coefficient = 0.17, p = 0.037) remained significantly different between SSc and healthy control groups (Cox and Snell R-2 = 0.243, Nagelkerke R-2 = 0.337, p < 0.001). NLR and MLR positively correlated with mRSS, EUSTAR score, and CRP. MLR also positively correlated with Medsger score. Higher monocyte counts independently predicted higher EUSTAR and Medsger scores in multiple linear regressions. Patients with digital ulcers had higher NLR and MLR. We did not find any difference in MPV values between SSc and healthy control groups. Conclusions Globally available and inexpensive hematological tests, particularly the NLR and MLR, may be associated with vascular and cutaneous manifestations as well as disease activity and severity in SSc.en_US
dc.identifier.doi10.1007/s10067-019-04685-0
dc.identifier.endpage83en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue1en_US
dc.identifier.pmid31317426en_US
dc.identifier.scopus2-s2.0-85069210751en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-019-04685-0
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19980
dc.identifier.volume39en_US
dc.identifier.wosWOS:000511726800010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectComplete Blood Counten_US
dc.subjectMLRen_US
dc.subjectMonocyte-To-Lymphocyte Ratioen_US
dc.subjectNeutrophil-To-Lymphocyte Ratioen_US
dc.subjectNLRen_US
dc.subjectSclerodermaen_US
dc.subjectSystemic Sclerosisen_US
dc.subjectCell Distribution Widthen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectLymphocyte Ratio Nlren_US
dc.subjectC-Reactive Proteinen_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.subjectRheumatoid-Arthritisen_US
dc.subjectRenal-Functionen_US
dc.subjectSclerodermaen_US
dc.subjectNeutrophilen_US
dc.subjectSurvivalen_US
dc.titleAssociation of simple hematological parameters with disease manifestations, activity, and severity in patients with systemic sclerosisen_US
dc.typeArticleen_US

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