Neutrophil to Lymphocyte Ratio and Serum Biomarkers : A Potential Tool for Prediction of Clinically Relevant Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage

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dc.authoridGUNAY, Burak/0000-0002-8462-7681
dc.authoridKAYABAS, Merve Yaren/0000-0001-8136-2326
dc.contributor.authorKula, Osman
dc.contributor.authorGunay, Burak
dc.contributor.authorKayabas, Merve Yaren
dc.contributor.authorAkturk, Yener
dc.contributor.authorKula, Ezgi
dc.contributor.authorTutunculer, Banu
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:51:41Z
dc.date.available2024-06-12T10:51:41Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective : Subarachnoid hemorrhage (SAH) is a condition characterized by bleeding in the subarachnoid space, often resulting from the rupture of a cerebral aneurysm. Delayed cerebral ischemia caused by vasospasm is a significant cause of mortality and morbidity in SAH patients, and inflammatory markers such as systemic inflammatory response index (SIRI), systemic inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), and derived NLR (dNLR) have shown potential in predicting clinical vasospasm and outcomes in SAH patients. This article aims to investigate the relationship between inflammatory markers and cerebral vasospasm after aneurysmatic SAH (aSAH) and evaluate the predictive value of various indices, including SIRI, SII, NLR, and dNLR, in predicting clinical vasospasm. Methods : A retrospective analysis was performed on a cohort of 96 patients who met the inclusion criteria out of a total of 139 patients admitted Trakya University Hospital with a confirmed diagnosis of aSAH between January 2013 and December 2021. Diagnostic procedures, neurological examinations, and laboratory tests were performed to assess the patients' condition. The Student's t-test compared age variables, while the chi-square test compared categorical variables between the non-vasospasm (NVS) and vasospasm (VS) groups. Receiver operating characteristic (ROC) curve analyses were used to evaluate the diagnostic accuracy of laboratory parameters, calculating the area under the ROC curve, cut-off values, sensitivity, and specificity. A significance level of p<0.05 was considered statistically significant. Results : The study included 96 patients divided into two groups : NVS and VS. Various laboratory parameters, such as NLR, SII, and dNLR, were measured daily for 15 days, and statistically significant differences were found in NLR on 7 days, with specific cut-off values identified for each day. SII showed a significant difference on day 9, while dNLR had significant differences on days 2, 4, and 9. Graphs depicting the values of these markers for each day are provided. Conclusion : Neuroinflammatory biomarkers, when used alongside radiology and scoring scales, can aid in predicting prognosis, determining severity and treatment decisions for aSAH, and further studies with larger patient groups are needed to gain more insights.en_US
dc.identifier.doi10.3340/jkns.2023.0157
dc.identifier.endpage689en_US
dc.identifier.issn2005-3711
dc.identifier.issn1598-7876
dc.identifier.issue6en_US
dc.identifier.pmid37634893en_US
dc.identifier.scopus2-s2.0-85176939221en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage681en_US
dc.identifier.urihttps://doi.org/10.3340/jkns.2023.0157
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18455
dc.identifier.volume66en_US
dc.identifier.wosWOS:001107708900003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Neurosurgical Socen_US
dc.relation.ispartofJournal Of Korean Neurosurgical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAneurysmal Subarachnoid Hemorrhageen_US
dc.subjectNeutrophil-To-Lymphocyte Ratioen_US
dc.subjectSystemic Immune-Inflammation Indexen_US
dc.subjectSystem Inflammation Response Indexen_US
dc.subjectSerum Markersen_US
dc.subjectCerebral Vasospasmen_US
dc.titleNeutrophil to Lymphocyte Ratio and Serum Biomarkers : A Potential Tool for Prediction of Clinically Relevant Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhageen_US
dc.typeArticleen_US

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