Changing cerebral blood flow velocity by transcranial Doppler during head up tilt in patients with diabetes mellitus

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dc.contributor.authorAsil, Talip
dc.contributor.authorUtku, Ufuk
dc.contributor.authorBalci, Kemal
dc.contributor.authorUzunca, Ilkay
dc.date.accessioned2024-06-12T11:16:34Z
dc.date.available2024-06-12T11:16:34Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Diabetes mellitus is an independent risk factor for poor prognosis in patients with ischemic stroke. It is known that diabetes mellitus directly affects cerebral vasculature as a secondary, long-term complication of cerebral circulation, and causes cerebral blood flow abnormalities. The abnormalities of cerebral autoregulation also poorly affects the prognosis of ischemic stroke. In this study, we aimed to show the cerebral autoregulation with transcranial Doppler (TCD) ultrasound in diabetic patients with autonomic nervous system abnormalities, determined with electrophysiological studies. Material and method: Twenty healthy controls and 39 patients, who had at least 2 years of diabetes mellitus, were evaluated (age ranges: 42-75 years). The patients were divided into two groups according to sympathetic skin response and R-R interval variation studies: (1) patients with autonomic neuropathy; (2) patients without autonomic neuropathy. Blood flow velocities were measured during supine position and after the patients were raised upright position on head up tilt table. Arterial blood pressures and heart rates were also evaluated. Results: Mean blood flow velocities of diabetic patients with autonomic neuropathy were found more decreased at 90 s after the patients were raised upright position. Discussion: Autonomic neuropathy due to diabetes mellitus affects cerebral autoregulation, and by this way cerebral perfusion loses protection against hemodynamical changes. (c) 2006 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.clineuro.2006.03.010
dc.identifier.endpage6en_US
dc.identifier.issn0303-8467
dc.identifier.issn1872-6968
dc.identifier.issue1en_US
dc.identifier.pmid16675103en_US
dc.identifier.scopus2-s2.0-33845209331en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2006.03.010
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24375
dc.identifier.volume109en_US
dc.identifier.wosWOS:000243588400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinical Neurology And Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTranscranial Doppleren_US
dc.subjectDiabetes Mellitusen_US
dc.subjectCerebral Autoregulationen_US
dc.subjectAutonomic Neuropathyen_US
dc.subjectCerebral Blood Flowen_US
dc.subjectCerebrovascular Reactivityen_US
dc.subjectSympathetic Activationen_US
dc.subjectUpright Tilten_US
dc.subjectRisk-Factoren_US
dc.subjectAutoregulationen_US
dc.subjectSonographyen_US
dc.subjectImpairmenten_US
dc.titleChanging cerebral blood flow velocity by transcranial Doppler during head up tilt in patients with diabetes mellitusen_US
dc.typeArticleen_US

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