The importance of speckle tracking echocardiography in the evaluation of cardiac functions in patients with rheumatoid arthritis

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dc.authoridemmungil, hakan/0000-0001-5184-4404
dc.authoridEBIK, MUSTAFA/0000-0002-0585-0958
dc.contributor.authorEbik, Muserref
dc.contributor.authorTastekin, Nurettin
dc.contributor.authorGurdogan, Muhammet
dc.contributor.authorEbik, Mustafa
dc.contributor.authorBirtane, Murat
dc.contributor.authorEmmungil, Hakan
dc.contributor.authorYilmazer, Baris
dc.date.accessioned2024-06-12T11:07:30Z
dc.date.available2024-06-12T11:07:30Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: In this study, we aimed to analyze the layer-specific strain values obtained by speckle tracking echocardiography (STE) method in the determination of subclinical cardiac dysfunction in rheumatoid arthritis (RA) patients. Patients and methods: Between February 2019 and October 2019, a total of 63 female RA patients (mean age: 51.82 +/- 6.07 years; range, 40 and 65 years) who had a confirmed diagnosis were included. Thirty-one age-matched female healthy individuals (mean age: 50.71 +/- 5.37 years; range, 40 and 65 years) were selected as the control group. The patients were divided into three groups according to the duration of disease as <5 years, 5-10 years and >10 years. The Disease Activity Score in 28 joint - C-reactive protein (CRP) was used to determine disease activation. The standard assessment included complete serum CRP, anti-cyclic citrullinated peptide, rheumatoid factor, N-terminal pro B-type natriuretic peptide (NT-proBNP), and homocysteine. Global longitudinal strain (GLS) analysis was performed with STE. Results: The NT-proBNP values were found to be higher in RA patients compared to the control group (p=0.044). In terms of conventional echocardiographic parameters, a significant difference between E/A and E/E' ratios was observed (p<0.001 and p=0.015). Endocardium, transmural, and epicardium GLS values obtained by STE were found to be lower in RA patients (p<0.05). The left ventricular (LV) GLS values worsened, as the duration of disease increased (p<0.05). There was a significant correlation between RA disease activity and LV GLS values, showing that increasing levels of disease activity was associated with worse LV GLS (r=0.583, p<0.01 and r=0.681, p<0.01 and r=0.689, p<0.01 for endocardium, transmural and epicardium, respectively). Conclusion: Our study results suggest that the layer-specific GLS values obtained by STE decrease in RA patients.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Uniten_US
dc.description.sponsorshippublication Funding: This study was financially supported by the Trakya University Scientific Research Projects Unit.en_US
dc.identifier.doi10.46497/ArchRheumatol.2024.10274
dc.identifier.issn2618-6500
dc.identifier.scopus2-s2.0-85194200123en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.46497/ArchRheumatol.2024.10274
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22072
dc.identifier.wosWOS:001158905500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish League Against Rheumatismen_US
dc.relation.ispartofArchives Of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLayer Specific Global Longitudinal Strainen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectSpeckle Tracking Echocardiographyen_US
dc.subjectHeart-Failureen_US
dc.subjectAssociationen_US
dc.subjectDysfunctionen_US
dc.subjectDiseaseen_US
dc.titleThe importance of speckle tracking echocardiography in the evaluation of cardiac functions in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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