The investigation of tumoral angiogenesis with HIF-1 alpha and microvessel density in women with endometrium cancer

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dc.authoridSAYIN, Cenk/0000-0001-7286-472X
dc.authorwosidSAYIN, Cenk/AAC-5802-2019
dc.contributor.authorAybatli, Aysun
dc.contributor.authorSayin, Cenk
dc.contributor.authorKaplan, Petek Balkanli
dc.contributor.authorVarol, Fusun
dc.contributor.authorAltaner, Semsi
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:00:24Z
dc.date.available2024-06-12T11:00:24Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Hypoxia inducible factor 1 alpha (HIF-1 alpha) is a nuclear protein upregulated in response to reduced cellular oxygen concentration which therefore acts as a marker for hypoxia. The aim of this study was to determine tumoral angiogenesis with immunohistochemical markers in endometrium cancer and its relation with stage, grade, survival rates and other prognostic factors. Material and Methods: Using the database in our Gynecologic Oncology clinic, we selected 94 patients who were diagnosed with endometrial cancer and underwent primary surgery at our institution between 2001 and 2010. Tissue microarrays believed to demonstrate the optimum part of the tumor were reprepared from the paraffin blocks. Angiogenesis and microvessel density (MVD) were investigated with the aid of HIF-1 alpha and CD34 antibodies. Results: High expression of HIF-1 alpha was significantly more frequent in advanced grade endometrial cancers (p=0.044). HIF-1 alpha expression was highly correlated with CD34 expression in the tumor cells (p<0.001). However lack of relation among stage, overall survival rates and histological types were analyzed with HIF-1 alpha. When we compared HIF-1 alpha positive and negative cases with cervical, adnexial, lymphovascular and myometrial invasion, there was no difference between these groups. MVD was evaluated with CD34 and it was remarkable and significantly different on advanced grade tumors (r=0.268; p=0.009). A similar significant difference was observed between the high expression of CD34 and type II endometrial cancer histology (p<0.001). However, there was no relationship between the MVD and stage or survival rates. Conclusion: High expression of HIF-1 alpha is associated with tumoral angiogenesis in endometrial adenocarcinomas. Further studies targeting HIF-1 alpha for disrupting mechanisms essential for tumor growth in endometrium cancer will be significant investigations in the future.en_US
dc.identifier.doi10.5152/jtgga.2012.02
dc.identifier.endpage44en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue1en_US
dc.identifier.pmid24627673en_US
dc.identifier.scopus2-s2.0-84858300180en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.5152/jtgga.2012.02
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20817
dc.identifier.volume13en_US
dc.identifier.wosWOS:000420646600008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal Of The Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometrium Canceren_US
dc.subjectHIF-1 Alphaen_US
dc.subjectHypoxiaen_US
dc.subjectAngiogenesisen_US
dc.subjectHypoxia-Inducible Factor-1-Alphaen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectFactor 1-Alphaen_US
dc.subjectExpressionen_US
dc.subjectHypoxia-Inducible-Factor-1-Alphaen_US
dc.subjectOverexpressionen_US
dc.subjectHif-1-Alphaen_US
dc.subjectMetastasisen_US
dc.subjectCarcinomaen_US
dc.subjectPrognosisen_US
dc.titleThe investigation of tumoral angiogenesis with HIF-1 alpha and microvessel density in women with endometrium canceren_US
dc.typeArticleen_US

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