The Protective Effect of Amifostine on Radiation-Induced Proctitis: Systemic Versus Topical Application

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dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridYağcı, Meral Apaydın/0000-0002-2108-1853
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosidYağcı, Meral Apaydın/AAY-6875-2021
dc.contributor.authorUzal, Cem
dc.contributor.authorSezer, Atakan
dc.contributor.authorUsta, Ufuk
dc.contributor.authorSut, Necdet
dc.contributor.authorOzen, Alaattin
dc.contributor.authorYagci, Mehmet All
dc.date.accessioned2024-06-12T10:51:24Z
dc.date.available2024-06-12T10:51:24Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to evaluate the radioprotective efficacy of intrarectal administration of amifostine in radiation-induced proctitis compared to intraperitoneal administration. Materials and Methods: Thirty-two Sprague-Dawley rats were randomly divided into four groups: Control (CONT), irradiation alone (RI), intraperitoneal amifostine plus irradiation (IPAMI), and intrarectal amifostine plus irradiation (IRAMI). The rats in the RI, IPAMI and IRAMI groups were irradiated individually with a single dose of 17.5 Gy to the pelvis. Amifostine was administered by the intraperitoneal (200 mg/kg) or intrarectal (2000 mg/kg) route before irradiation. Histopathologic analysis of the rectum was performed 14 days after irradiation. Results: Significant radiation damage appeared in all histopathologic parameters and was reduced by amifostine. Pretreatment with IPAMI significantly reduced the inflammatory infiltrate in the lamina propria (p=0.021), cryptitis (p=0.002) and crypt abscess (p=0.015). However, the protective effect of IRAMI was significant for all parameters with equal or higher significance than IPAMI, including the eosinophil leucocytes count (p=0.02), and distortion of the crypts (p=0.008), and was also significant for regenerative/reparative atypia (p=0.013). Conclusion: Intrarectal high dose topical administration of amifostine is more effective in the prevention of radiation-induced proctitis compared to its intraperitoneal systemic administration.en_US
dc.identifier.doi10.5152/balkanmedj.2011.005
dc.identifier.endpage38en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84862112912en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2011.005
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18357
dc.identifier.volume29en_US
dc.identifier.wosWOS:000303618400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmifostineen_US
dc.subjectProctitisen_US
dc.subjectIrradiationen_US
dc.subjectRadioprotectionen_US
dc.subjectLate Rectal Injuryen_US
dc.subjectSmall-Intestineen_US
dc.subjectIntrarectal Amifostineen_US
dc.subjectProstate-Canceren_US
dc.subjectRat Modelen_US
dc.subjectRadiotherapyen_US
dc.subjectTherapyen_US
dc.subjectPreventionen_US
dc.subjectToxicityen_US
dc.subjectFractionationen_US
dc.titleThe Protective Effect of Amifostine on Radiation-Induced Proctitis: Systemic Versus Topical Applicationen_US
dc.typeArticleen_US

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