Diagnostic value of plasma fibronectin level in predicting the presence and severity of coronary artery disease

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dc.authorwosidAKTOZ, MERYEM/M-9023-2018
dc.contributor.authorOzcelik, Fatih
dc.contributor.authorErdogan, Okan
dc.contributor.authorAktoz, Meryem
dc.contributor.authorEkuklu, Galip
dc.contributor.authorTatli, Ersan
dc.contributor.authorDemir, Muzaffer
dc.date.accessioned2024-06-12T11:01:56Z
dc.date.available2024-06-12T11:01:56Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe relation between fibronectin and coronary artery disease (CAD) according to previous study results is controversial. The aim of the present study is to investigate the predictive value of fibronectin in determining the presence and severity of CAD. Patients with stable angina (n = 62) who had angiographically documented CAD, and control patients (n = 31) who had normal coronary angiograms, were included in the study. Plasma fibronectin levels were determined in all patients. Plasma fibronectin level (milligrams per liter) in patients with CAD was higher than normal controls (364.2 +/- 171 vs 265.1 +/- 135.5, p = 0.006). The severity of CAD determined according to Gensini score and fibronectin level did not show any correlation (r = 0.13, p = 0.311). If fibronectin level 240 mg/l was determined as cutoff, it showed 76% sensitivity, 46% specificity, 46% negative predictive value, and 72.3% positive predictive value for predicting CAD. The present study showed that plasma fibronectin level in CAD is significantly higher than normal control subjects. However, it has no role in predicting the severity of CAD.en_US
dc.identifier.doi10.1007/s00277-008-0573-x
dc.identifier.endpage253en_US
dc.identifier.issn0939-5555
dc.identifier.issue3en_US
dc.identifier.pmid18716775en_US
dc.identifier.scopus2-s2.0-59049107138en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage249en_US
dc.identifier.urihttps://doi.org/10.1007/s00277-008-0573-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21087
dc.identifier.volume88en_US
dc.identifier.wosWOS:000262649700009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals Of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibronectinen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectIschemiaen_US
dc.subjectHeart-Diseaseen_US
dc.subjectAtherosclerosisen_US
dc.subjectGlycoproteinen_US
dc.subjectAssociationen_US
dc.subjectAdhesionen_US
dc.titleDiagnostic value of plasma fibronectin level in predicting the presence and severity of coronary artery diseaseen_US
dc.typeArticleen_US

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