Relationship between arginase genes polymorphisms and preschool wheezing phenotypes

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dc.authoridCelik, Velat/0000-0002-8893-9420
dc.authoridBeken, Burcin/0000-0001-7677-7690;
dc.authorwosidCelik, Velat/IUN-0044-2023
dc.authorwosidBeken, Burcin/GPK-8389-2022
dc.authorwosidYazicioglu, Mehtap/AAB-9587-2022
dc.contributor.authorGokmirza Ozdemir, Pinar
dc.contributor.authorEker, Damla
dc.contributor.authorCelik, Velat
dc.contributor.authorBeken, Burcin
dc.contributor.authorGurkan, Hakan
dc.contributor.authorYazicioglu, Mehtap
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:52:28Z
dc.date.available2024-06-12T10:52:28Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground The association between arginase I (ARG1) and arginase II (ARG2) genes and asthma has been reported in previous studies, but associations between polymorphisms in ARG genes and preschool wheezing (PSW) phenotypes are still unknown. Objective To examine the association between genetic variation in ARG1 and ARG2 genes and PSW phenotypes. Methods We enrolled 83 patients and 86 healthy controls. The patient group included two subgroups: episodic wheezing (EW) (n = 42, median age 41 months) and multiple-trigger wheezing (MW) (n = 41, median age 39 months). We genotyped six single nucleotide polymorphisms (SNPs) in ARG1 and six SNPs in ARG2. Eighteen haplotypes for ARG1 and 31 haplotypes for ARG2 were constituted, and the distributions of SNPs and haplotypes in patients and controls were analyzed. Results The frequency of the homozygote cytosine-cytosine (CC) genotype of ARG1 rs2781667T>C SNP and the ARG1 haplotype 4 in the MW group was significantly higher than the EW group (p = .002; odd ratios [OR]: 5.25; confidence interval [CI]: 1.9-14.51 and p < .001; OR: 7.77; CI: 2.54-23.74, respectively). The frequency of the ARG1 haplotype 5 was significantly higher but the frequency of ARG1 haplotype 9 was significantly lower in the all patients than in the healty controls (p = .019; OR: 10.34; CI: 1.28-83.53 and p = .015; OR: 0.093; CI:0.01-0.74, respectively). The frequency of the ARG1 haplotype 2 was significantly higher in the EW group than in the MW group (p = .014; OR: 5.68; CI: 1.48-21.8). Conclusion Variations in ARG1 may potentially be related to phenotypes and risk of PSW.en_US
dc.description.sponsorshipResearch Council of Trakya University [2017/86]en_US
dc.description.sponsorshipResearch Council of Trakya University, Grant/Award Number: 2017/86en_US
dc.identifier.doi10.1002/ppul.25202
dc.identifier.endpage570en_US
dc.identifier.issn8755-6863
dc.identifier.issn1099-0496
dc.identifier.issue2en_US
dc.identifier.pmid33369279en_US
dc.identifier.scopus2-s2.0-85097957494en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage561en_US
dc.identifier.urihttps://doi.org/10.1002/ppul.25202
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18716
dc.identifier.volume56en_US
dc.identifier.wosWOS:000601272800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Pulmonologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectARG1en_US
dc.subjectARG2en_US
dc.subjectPolymorphismen_US
dc.subjectPreschool Wheezingen_US
dc.subjectRecurrent Wheezingen_US
dc.subjectSingle Nucleotideen_US
dc.subjectSNPen_US
dc.subjectWheezing Phenotypeen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectAsthmaen_US
dc.subjectExpressionen_US
dc.subjectArg1en_US
dc.subjectChildrenen_US
dc.subjectPathwayen_US
dc.titleRelationship between arginase genes polymorphisms and preschool wheezing phenotypesen_US
dc.typeArticleen_US

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