Modulatory role of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine (ADMA), in morphine tolerance and dependence in mice

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorKaradag, Cetin Hakan
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T11:08:43Z
dc.date.available2024-06-12T11:08:43Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractElevated plasma asymmetric dimethylarginine (ADMA) levels have been implicated in many cardiovascular and metabolic disorders. In the current work, we investigated the hypothesis that peripheral ADMA is an important contributor to opioid tolerance and dependence, by determining plasma ADMA levels during the development of tolerance and dependence to morphine in mice. Tolerance to and dependence on morphine were induced by repeated injections of morphine (10 mg/kg, s.c.) twice daily to male mice, divided into groups of 3-, 6-, 9- and 10-day injection duration. The loss of antinociceptive effect of morphine in the tail flick test was used for evaluating the degree of tolerance. Physical dependence was assessed following the administration of a 5 mg/kg dose of naloxone, by counting the occurrence of withdrawal jumps and forepaw tremors for 20 min. At the end of each period, animals were anesthetized and blood samples were collected from carotid artery. The plasma levels of ADMA, symmetric dimethylarginine (SDMA), l-homoarginine and l-arginine in morphine-tolerant and -dependent mice were not different from duration-matched control mice. Similarly, no difference was observed in plasma ADMA and the other molecules concentrations between groups of mice with different stages of development of tolerance and dependence. Our results suggest that endogenous plasma ADMA, SDMA, l-homoarginine and l-arginine levels remain unchanged during the development of morphine tolerance and dependence, and are not associated with these phenomena.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-2009/60]en_US
dc.description.sponsorshipThis work was supported by a Grant from Trakya University Research Council (TUBAP-2009/60). The authors have no conflicts of interests to report.en_US
dc.identifier.doi10.1007/s00702-010-0443-2
dc.identifier.endpage1032en_US
dc.identifier.issn0300-9564
dc.identifier.issue9en_US
dc.identifier.pmid20661755en_US
dc.identifier.scopus2-s2.0-85027937716en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1027en_US
dc.identifier.urihttps://doi.org/10.1007/s00702-010-0443-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22544
dc.identifier.volume117en_US
dc.identifier.wosWOS:000281397200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofJournal Of Neural Transmissionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMorphineen_US
dc.subjectToleranceen_US
dc.subjectDependenceen_US
dc.subjectNitric Oxideen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectL-Arginine Paradoxen_US
dc.subjectOpioid Toleranceen_US
dc.subjectAntinociceptive Toleranceen_US
dc.subjectPhysical-Dependenceen_US
dc.subjectAbstinence Syndromeen_US
dc.subjectNervous-Systemen_US
dc.subjectReceptoren_US
dc.subjectPainen_US
dc.subjectPerspectivesen_US
dc.subjectPharmacologyen_US
dc.titleModulatory role of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine (ADMA), in morphine tolerance and dependence in miceen_US
dc.typeArticleen_US

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