Investigation of The Relationship Between IL-18 (-607 C/A), IL-18 (-137 G/C) Gene Variations and Ischemic Stroke Disease Development in Thrace Region of Turkey

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dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authorwosidKEHAYA, Sezgin/GVU-6069-2022
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.authorwosidKEHAYA, Sezgin/P-6106-2019
dc.authorwosidKEHAYA, Sezgin/N-9995-2017
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorAy, Arzu
dc.contributor.authorKehaya, Sezgin
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:07:07Z
dc.date.available2024-06-12T11:07:07Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground Ischemic stroke is a clinical condition characterized by focal or global cerebral dysfunction resulting from inhibition of brain blood flow. Genetic factors play an important role in the pathogenesis of ischemic stroke. As a result of IL-18 (-607 C/A, -137 G/C) gene variations, it is thought that binding of transcription factors may be affected and IL-18 mRNA expression can be modulated. Therefore, the purpose of our study is to investigate the roles of IL-18 (-607 C/A), IL-18 (-137 G/C) gene variations in the development of ischemic stroke in Trakya Region of Turkey. Methods Our study was performed with 90 ischemic stroke patients and 89 healthy controls. Genotype distributions of IL-18 (-607 C/A, -137 G/C) gene variations were determined using polymerase chain reaction (PCR) method. Results GC genotype and CA genotype of IL-18 (-137 G/C) and IL-18 (-607 C/A) gene variations were determined higher significantly in patent group as compared with other genotypes. However, the statistically significant difference was not determined between patients with ischemic stroke and healthy control groups in terms of IL-18 (-137 G/C) and IL-18 (-607 C/A) gene variations (p> 0,05). Allele frequencies of IL-18 (-137 G/C) and IL-18 (-607 C/A) in patient and control groups were significantly different from the Hardy-Weinberg distribution (p< .001 for all). Conclusion Although these gene variations' genotype distributions were not determined as a genetic risk factor for the development of ischemic stroke, allele frequencies of IL-18 (-137 G/C) and IL-18 (-607 C/A) in patient and control groups were significantly different from the Hardy-Weinberg distribution.en_US
dc.identifier.doi10.1080/08820139.2020.1782932
dc.identifier.endpage645en_US
dc.identifier.issn0882-0139
dc.identifier.issn1532-4311
dc.identifier.issue6en_US
dc.identifier.pmid32573302en_US
dc.identifier.scopus2-s2.0-85087353134en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage634en_US
dc.identifier.urihttps://doi.org/10.1080/08820139.2020.1782932
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21901
dc.identifier.volume50en_US
dc.identifier.wosWOS:000547771300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofImmunological Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemic Strokeen_US
dc.subjectIL-18 Geneen_US
dc.subjectIL-18 (-607 Cen_US
dc.subjectA) Gene Variationen_US
dc.subjectIL-18 (-137 Gen_US
dc.subjectC) Gene Variationen_US
dc.subjectPCRen_US
dc.subjectInterleukin-18en_US
dc.subjectPolymorphismsen_US
dc.subjectPromoteren_US
dc.subjectRisken_US
dc.subjectSusceptibilityen_US
dc.subjectAssociationen_US
dc.subjectPopulationen_US
dc.subjectMechanismsen_US
dc.subjectInfectionen_US
dc.subjectImpacten_US
dc.titleInvestigation of The Relationship Between IL-18 (-607 C/A), IL-18 (-137 G/C) Gene Variations and Ischemic Stroke Disease Development in Thrace Region of Turkeyen_US
dc.typeArticleen_US

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