Regional cerebral blood flow abnormalities in patients with primary hyperparathyroidism

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dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277;
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.authorwosidBEDEL, Deniz/AAZ-4407-2020
dc.contributor.authorCermik, Tevfik Fikret
dc.contributor.authorKaya, Meryem
dc.contributor.authorUgur-Altun, Betuel
dc.contributor.authorBedel, Deniz
dc.contributor.authorBerkarda, Sakir
dc.contributor.authorYigitbasi, Oemer N.
dc.date.accessioned2024-06-12T11:12:52Z
dc.date.available2024-06-12T11:12:52Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction We assessed the alterations in regional cerebral blood flow (rCBF) in patients with primary hyperparathyroidism (PHP) before parathyroidectomy by semiquantitative analysis of brain single photon emission computed tomography ( SPECT) images. Methods Included in this prospective study were 14 patients ( mean age 47.6 +/- 10.4 years; 3 male, 11 female) and 10 control subjects ( mean age 36.0 +/- 8.5 years, 6 male, 4 female) were SPECT imaging was performed using a dual-headed gamma camera 60 - 90 min after intravenous administration of 925 MBq Tc-99m HMPAO. The corticocerebellar rCBF ratios were calculated from 52 brain areas and reference lower values (RLVs) were calculated from the rCBF ratios of control subjects. The regional ratios that were below the corresponding RLV were considered abnormal (hypoperfused). Results Hypoperfusion was shown in 171 out of 728 regions (23%) and there was a significant correlation between serum calcium, PTH levels and the sum of hypoperfused regions in the patient group (R= 0.75 and P= 0.001, and R= 0.75, P= 0.001, respectively). Significantly reduced rCBF were found in the following cortical regions: bilateral cingulate cortex, superior and inferior frontal cortex, anterior temporal cortex, precentral gyrus, postcentral gyrus and parietal cortex, and right posterior temporal cortex. Conclusion Our results indicate that alterations in rCBF in patients with PHP can be demonstrated with brain SPECT. The correlation between serum calcium, PTH levels and the sum of hypoperfused regions indicates that there may be a strong relationship between rCBF abnormalities and increased levels of serum calcium and PTH. In addition, the degree of rCBF abnormalities could be determined by brain SPECT in PHP patients with or without psychiatric symptoms.en_US
dc.identifier.doi10.1007/s00234-006-0198-5
dc.identifier.endpage385en_US
dc.identifier.issn0028-3940
dc.identifier.issn1432-1920
dc.identifier.issue4en_US
dc.identifier.pmid17205311en_US
dc.identifier.scopus2-s2.0-34047187930en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://doi.org/10.1007/s00234-006-0198-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23340
dc.identifier.volume49en_US
dc.identifier.wosWOS:000245298600012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeuroradiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrimary Hyperparathyroidismen_US
dc.subjectPTHen_US
dc.subjectCalciumen_US
dc.subjectRegional Cerebral Blood Flowen_US
dc.subjectTc-99m HMPAOen_US
dc.subjectBrain SPECTen_US
dc.subjectObsessive-Compulsive Patientsen_US
dc.subjectEmission Computed-Tomographyen_US
dc.subjectPsychiatric Morbidityen_US
dc.subjectParathyroid-Hormoneen_US
dc.subjectMajor Depressionen_US
dc.subjectSurgical-Correctionen_US
dc.subjectManifestationsen_US
dc.subjectDisorderen_US
dc.subjectSymptomsen_US
dc.subjectHypercalcemiaen_US
dc.titleRegional cerebral blood flow abnormalities in patients with primary hyperparathyroidismen_US
dc.typeArticleen_US

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