Comparison of Protective Effects of L-Carnitine and Amifostine on Radiation-induced Toxicity to Growing Bone: Histopathology and Scintigraphy Findings

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorDurmus-Altun, Gulay
dc.contributor.authorCaloglu, Murat
dc.contributor.authorUsta, Ufuk
dc.contributor.authorSaynak, Mert
dc.contributor.authorUzal, Cem
dc.contributor.authorCosar-Alas, Rusen
dc.date.accessioned2024-06-12T10:51:23Z
dc.date.available2024-06-12T10:51:23Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: The aim of the present study was to evaluate the radioprotective efficacy of L-carnitine (LC) in growing bones in comparison to amifostine. Materials and Methods: Sixty two-week-old Wistar albino rats were randomly assigned to six equal groups: Group 1, control (CONT); Group 2, irradiation alone (RT); Group 3, amifostine plus irradiation (AMI+RT); Group 4, L-carnitine plus irradiation (LC+RT); Group 5, amifostine alone (AMI); Group 6, L-carnitine alone (LC). The rats in the AMI+RT, LC+RT and RT groups were irradiated individually with a single dose of 20 Gy to the left femur. LC (300mg/kg) and amifostine (200mg/kg) were applied 30 min before irradiation. The animals were scanned for bone area, mineral content and bone mineral density (BMD) by DEXA and the 99mTc methylene diphosphonate uptake ratio (MUR) was calculated by bone scintigraphy. Histopathological analysis of bone and cartilage was also carried out after euthanasia. Results: Pretreatment with LC or amifostine reduced the radiation-induced damage in growing bone (p=0.007 and p=0.04 respectively) and in the epiphysial cartilage (p=0.002 and p=0.015 respectively). The protective effect of LC was similar to that of amifostine on both growing bone and on the epiphysial cartilage. The mean left-femur BMD values were significantly higher in the LC+RT (p=0.02) and AMI+RT (p=0.01) groups than in the RT group. but did not differ with the two protective agents. Pretreatment with AMI (p=0.002) and LC (p=0.01) improved the MUR. Conclusions: L-carnitine is equally as effective as amifostine at protecting growing bone against single dose irradiation damage.en_US
dc.identifier.endpage667en_US
dc.identifier.issn1513-7368
dc.identifier.issue3en_US
dc.identifier.pmid21039033en_US
dc.identifier.scopus2-s2.0-78650691458en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage661en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18349
dc.identifier.volume11en_US
dc.identifier.wosWOS:000285641400014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal Of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectGrowing Boneen_US
dc.subjectIrradiationen_US
dc.subjectL-Carnitineen_US
dc.subjectRadioprotectionen_US
dc.subjectThyroid-Hormone Actionen_US
dc.subjectL-Propionyl-Carnitineen_US
dc.subjectRat Modelen_US
dc.subjectOxidative Stressen_US
dc.subjectInduced Damageen_US
dc.subjectIn-Vitroen_US
dc.subjectRadioprotectant Drugsen_US
dc.subjectIonizing-Radiationen_US
dc.subjectGrowthen_US
dc.subjectIrradiationen_US
dc.titleComparison of Protective Effects of L-Carnitine and Amifostine on Radiation-induced Toxicity to Growing Bone: Histopathology and Scintigraphy Findingsen_US
dc.typeArticleen_US

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