Acute radiation effect in the brain in infant rats: Neurocognitive and histopathological examination

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dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorGorker, I.
dc.contributor.authorYurut-Caloglu, V.
dc.contributor.authorKaradag, H.
dc.contributor.authorCaloglu, M.
dc.contributor.authorAltaner, S.
dc.contributor.authorCengiz, H.
dc.contributor.authorOzen, A.
dc.date.accessioned2024-06-12T10:51:23Z
dc.date.available2024-06-12T10:51:23Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: The aim of the present study was to evaluate the radiation-induced cognitive dysfunction and the radioprotective effect of amifostine (AMI) in the brain of infantile rats. Methods: Thirty 2-week-old rats were randomly assigned into 3 groups of 10 rats each. Group 1 : control (CONT), group 2: radiation alone (RT), and group 3: AMI before radiation (AMI+RT). The rats in the RT and AMI+RT groups were irradiated individually with a single dose of 20 Gy. All animals were evaluated by using the Morris water maze test to evaluate of their cognitive functions. Histopathological analyses of the hippocampus were also carried out after euthanasia. Results: The study showed that the place navigational function and the spatial probe test were not significantly different between the groups. Conclusion: It can be said that it is very important to determine when the radiation-induced brain injury is formed. From a clinical perspective, the patients can be intervened before irreversible functional deficits are formed and may be amenable to treatment.en_US
dc.identifier.endpage303en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue2en_US
dc.identifier.pmid21766501en_US
dc.identifier.scopus2-s2.0-79960224706en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18348
dc.identifier.volume16en_US
dc.identifier.wosWOS:000292578200016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal Of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectCognitive Dysfunctionen_US
dc.subjectIrradiationen_US
dc.subjectRadioprotectionen_US
dc.subjectDentate Gyrusen_US
dc.subjectAdulten_US
dc.subjectNeurogenesisen_US
dc.subjectIrradiationen_US
dc.subjectHippocampusen_US
dc.subjectAmifostineen_US
dc.subjectCellsen_US
dc.titleAcute radiation effect in the brain in infant rats: Neurocognitive and histopathological examinationen_US
dc.typeArticleen_US

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