Effect of perinatal biotin deficiency on auditory pathway of the Wistar-Albino rats

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dc.authoridCilingir-Kaya, Ozlem Tugce/0000-0002-2591-9174
dc.authoridEnsari, Nuray/0000-0002-3373-9173
dc.authorid, erdogan/0000-0003-2036-6870
dc.authorwosidyılmaz, nevreste didem sonbay/AAC-7589-2020
dc.authorwosidkaya, ozlem/KFS-7716-2024
dc.authorwosidCilingir-Kaya, Ozlem Tugce/P-9830-2015
dc.authorwosiddanisman, betul/I-8116-2017
dc.authorwosidEnsari, Nuray/AAC-9791-2020
dc.authorwosidgür, özer/ABE-7511-2020
dc.authorwosid, erdogan/C-4135-2015
dc.contributor.authorYllmaz, Nevreste Didem Sonbay
dc.contributor.authorGur, Ozer Erdem
dc.contributor.authorEnsari, Nuray
dc.contributor.authorBulut, Erdogan
dc.contributor.authorKaya, Ozlem Tugce
dc.contributor.authorSirvanci, Serap
dc.contributor.authorDanisman, Betul
dc.date.accessioned2024-06-12T10:54:41Z
dc.date.available2024-06-12T10:54:41Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: Severe biotin deficiency associated with biotinidase enzyme deficiency in newborns is seen as severe neurological problems and hearing loss. However, the effect on the infant of deficiencies in the maternal diet during pregnancy are not clear. Material and methods: The study included 16 female Wistar albino rats and 4 male Wistar albino rats, that were mated and then the females were separated into 4 groups. At 40 days after the birth, 3 pups were selected from each group, and these 12 pups were evaluated with DPOAE and ABR electrophysiologically and the cochlea was examined ultrastructurally with electron microscopy. Results: In the DPOAE evaluation, At 8000 and 11,000 Hz, the signal-noise ratios in the B-N and B-B groups were statistically significantly higher (p < .05). In ABR, lengthening of the latency periods was determined in all the waves at both 8 and 16 kHz in the B-B group. When the IPL periods were examined, lengthening in IPL 1-5 was statistically significant in the B-B group only at 8 kHz. Conclusions: Biotin can be said to have an effect on hearing pathways. However, specifically where on the hearing pathways that biotin is involved has not been clarified.en_US
dc.description.sponsorshipScientific Research Projects Commission of the Medical Specialists Training Committee of Health Sciences University Antalya Training and Research Hospital [81266704-869]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Commission of the Medical Specialists Training Committee of Health Sciences University Antalya Training and Research Hospital (Project no: 81266704-869, dated: 17/01/2017).en_US
dc.identifier.doi10.1080/00016489.2019.1614665
dc.identifier.endpage684en_US
dc.identifier.issn0001-6489
dc.identifier.issn1651-2251
dc.identifier.issue8en_US
dc.identifier.pmid31124733en_US
dc.identifier.scopus2-s2.0-85066891962en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage677en_US
dc.identifier.urihttps://doi.org/10.1080/00016489.2019.1614665
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19148
dc.identifier.volume139en_US
dc.identifier.wosWOS:000469711200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Oto-Laryngologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiotinen_US
dc.subjectHearing Pathwayen_US
dc.subjectDPOAEen_US
dc.subjectABRen_US
dc.subjectElectron Microscopyen_US
dc.subjectHearing-Lossen_US
dc.subjectDeafnessen_US
dc.titleEffect of perinatal biotin deficiency on auditory pathway of the Wistar-Albino ratsen_US
dc.typeArticleen_US

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