High C-reactive protein and low cholesterol levels are prognostic markers of survival in severe sepsis

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dc.contributor.authorMemis, Dilek
dc.contributor.authorGursoy, Olcay
dc.contributor.authorTasdogan, Muhittin
dc.contributor.authorSut, Necdet
dc.contributor.authorKurt, Imran
dc.contributor.authorTure, Mevlut
dc.contributor.authorKaramanlioglu, Beyhan
dc.date.accessioned2024-06-12T10:58:51Z
dc.date.available2024-06-12T10:58:51Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractStudy Objective: To evaluate serum C-reactive protein and cholesterol as a prognostic factor for Survival in patients with severe sepsis. Design: Prospective study. Setting: University hospital. Patients: The study population consisted of 96 patients (age range, 18-75 years; median, 56 years; men/women ratio, 40:56) in whom severe sepsis was diagnosed. Interventions: Patients' serum levels of C-reactive protein and cholesterol were measured upon admission to an intensive care unit, two days later, and on the day of discharge from the intensive care unit or on the day of death. Measurements and Main Results: Cholesterol levels were significantly lower among the nonsurviving patients (day 1, 92.2 +/- 25.1 mg/dL; day 2, 92.1 +/- 21.7 mg/dL; death/discharge day, 92.2 +/- 21.7 mg/dL) than surviving patients (day 1, 175.1 +/- 38.6 mg/dL [P < 0.001]; day 2, 173.0 +/- 39.3 mg/dL [P < 0.001]; death/discharge day, 171.8 +/- 39.6 mg/dL [P = 0.010]). Median C-reactive protein levels were significantly higher among the nonsurvivors (day 1, 32 mg/dL [range, 20.5-64.5 rng/dL]; day 2, 33 mg/dL [range, 22-74.5 mg/dL]; death/discharge day, 30 rng/dL [range, 22-57 mg/dL]) than survivors (day 1, 10 rng/dL [range, 6-14 mg/dL]; day 2, 9 mg/dL [range, 5-10 mg/dL]; death/discharge day, 6 mg/dL [range, 3-9 mg/dL]; P < 0.001). Conclusion: Serum C-reactive protein and cholesterol are a predictor of survival in patients with severe sepsis. Low cholesterol and high C-reactive protein levels appear as a valuable tool for individual risk assessment in severe sepsis patients and for stratification of high-risk patients in future intervention trials. (C) 2007 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jclinane.2006.10.008
dc.identifier.endpage191en_US
dc.identifier.issn0952-8180
dc.identifier.issue3en_US
dc.identifier.pmid17531726en_US
dc.identifier.scopus2-s2.0-34248668163en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage186en_US
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2006.10.008
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20207
dc.identifier.volume19en_US
dc.identifier.wosWOS:000247128200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Clinical Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectCholesterolen_US
dc.subjectPrognostic Factoren_US
dc.subjectSevere Sepsisen_US
dc.subjectMultiple Organ Failureen_US
dc.subjectCritically-Ill Patientsen_US
dc.subjectIntensive-Care-Uniten_US
dc.subjectBlunt Traumaen_US
dc.subjectCytokineen_US
dc.subjectHypocholesterolemiaen_US
dc.subjectIndicatoren_US
dc.subjectEndotoxinen_US
dc.subjectKineticsen_US
dc.subjectDecreaseen_US
dc.titleHigh C-reactive protein and low cholesterol levels are prognostic markers of survival in severe sepsisen_US
dc.typeArticleen_US

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