The Association between Platelet/Lymphocyte Ratio and Coronary Artery Disease Severity in Asymptomatic Low Ejection Fraction Patients

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dc.authoridÖzeke, Özcan/0000-0002-4770-8159
dc.authoridACAR, BURAK/0000-0003-3217-5000;
dc.authorwosidÖzeke, Özcan/AAS-8730-2020
dc.authorwosidGÜL, Murat/AAH-7852-2021
dc.authorwosidÖzeke, Özcan/N-1871-2015
dc.authorwosidGUL, Murat/L-5770-2015
dc.authorwosidACAR, BURAK/ABD-9011-2021
dc.authorwosidAcar, Burak/GVT-1660-2022
dc.contributor.authorUcar, Fatih Mehmet
dc.contributor.authorAcar, Burak
dc.contributor.authorGul, Murat
dc.contributor.authorOzeke, Ozcan
dc.contributor.authorAydogdu, Sinan
dc.date.accessioned2024-06-12T11:07:52Z
dc.date.available2024-06-12T11:07:52Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and Objectives: Coronary angiography (CAG) is generally needed in the setting of systolic heart failure (HF) with an unidentified etiology as a part of diagnostic strategy. On the other hand, the clinical value of this invasive strategy is largely unknown. Platelet-lymphocyte ratio (PLR) has recently emerged as a novel inflammatory index that may serve as an important predictor of inflammatory state and overall mortality. The present study aimed to search the predictive value of PLR in determining the extent of coronary atherosclerosis in asymptomatic low ejection fraction (EF) patients. Subjects and Methods: 156 asymptomatic heart failure (HF) subjects (without angina or HF symptoms, mean age: 58 years; to male: 71.2% were enrolled, and thereafter a CAG was performed. Gensini Score was used to determine the severity of coronary artery disease (CAD) on CAG. According to this scoring system, the overall study group was categorized into three distinct subgroups: control group with the score 0, mild atherosclerosis group with the score 0 to 20 and severe atherosclerosis group with the score of >20. Thereafter, a comparison was made among groups with regard to mean values of PLR. Results:The severe atherosclerosis group had a substantially higher level of mean PLR in comparison to other groups (p<0.001). Pre-CAG PLR levels as well as a variety of clinical variables including age, low density lipoprotein (LDL)-cholesterol demonstrated an independent correlation with Gensini score through a multivariate analysis. Conclusion: These findings suggest the potential association of high PLR levels with severe atherosclerosis in the setting of asymptomatic systolic HF. A simple measurement of PLR helps to identify the severity of coronary atherosclerosis prior to conducting coronary angiography.en_US
dc.identifier.doi10.4070/kcj.2016.46.6.821
dc.identifier.endpage826en_US
dc.identifier.issn1738-5520
dc.identifier.issn1738-5555
dc.identifier.issue6en_US
dc.identifier.pmid27826341en_US
dc.identifier.scopus2-s2.0-84994626904en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage821en_US
dc.identifier.urihttps://doi.org/10.4070/kcj.2016.46.6.821
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22202
dc.identifier.volume46en_US
dc.identifier.wosWOS:000387737700012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Soc Cardiologyen_US
dc.relation.ispartofKorean Circulation Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLow Ejection Fractionen_US
dc.subjectAsymptomatic Diseaseen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectGensini Scoreen_US
dc.subjectPlatelet-Lymphocyte Ratioen_US
dc.subjectPlatelet-Lymphocyte Ratioen_US
dc.subjectHeart-Failureen_US
dc.subjectNeutrophilen_US
dc.subjectMortalityen_US
dc.subjectCounten_US
dc.subjectMechanismsen_US
dc.subjectOutcomesen_US
dc.subjectDeathen_US
dc.titleThe Association between Platelet/Lymphocyte Ratio and Coronary Artery Disease Severity in Asymptomatic Low Ejection Fraction Patientsen_US
dc.typeArticleen_US

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