Contribution of spinal 5-HT5A receptors to the antinociceptive effects of systemically administered cannabinoid agonist WIN 55,212-2 and morphine

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.contributor.authorAksu, Ahmet Goktan
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:52:02Z
dc.date.available2024-06-12T10:52:02Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe antinociceptive effects of cannabinoids and opioids have been known for centuries. Serotonin and its receptors are also known to play important roles in nociception. However, the contribution of spinal 5-HT5A receptors in antinociceptive effects of cannabinoids and opioids has not been studied. We conducted this study to clarify spinal mechanisms of the actions of the antinociceptive effects of cannabinoids and opioids. Hot plate and tail fl(i)ck tests were used to assess the antinociceptive activity in Balb/c mice. WIN 55,212-2, a nonselective CB1 and CB2 agonist, and morphine exerted significant antinociceptive effects at 1, 3, and 10 mg/kg doses administered intraperitoneally in both hot plate and tail flick tests. The selective 5-HT5A receptor antagonist SB-699551 (10 nmol/mouse) was administered intrathecally 10 min before the agonists. SB-699551 significantly reduced the antinociceptive effect of both WIN 55,212-2 and morphine. In the rotarod test, WIN 55,212-2 disrupted the motor coordination at a dose of 10 mg/kg, while morphine did not affect this function at any dose. Our findings show that spinal 5-HT5A receptors are involved in the antinociceptive effects of WIN 55,212-2 and morphine.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-2106/44]en_US
dc.description.sponsorshipThis project was supported by a grant from Trakya University Research Council (TUBAP-2106/44). We thank K. Duvan-Aydemir for her technical support for behavioral analysis. This paper was presented at the 6th Mediterranean Neuroscience Society Conference held in St. Julian's, Malta, on 12-15 June 2017.en_US
dc.identifier.doi10.1139/cjpp-2017-0567
dc.identifier.endpage623en_US
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.issue6en_US
dc.identifier.pmid29406831en_US
dc.identifier.scopus2-s2.0-85048173433en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage618en_US
dc.identifier.urihttps://doi.org/10.1139/cjpp-2017-0567
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18577
dc.identifier.volume96en_US
dc.identifier.wosWOS:000434045000011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Science Publishing, Nrc Research Pressen_US
dc.relation.ispartofCanadian Journal Of Physiology And Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntinociceptionen_US
dc.subjectMorphineen_US
dc.subjectSB-699551en_US
dc.subjectSpinal 5-HT5A Receptorsen_US
dc.subjectWIN 55,212-2en_US
dc.subjectNeuropathic Painen_US
dc.subjectNoradrenergic Systemsen_US
dc.subjectTherapeutic Targeten_US
dc.subjectNerve Injuryen_US
dc.subjectRat Modelen_US
dc.subjectSerotoninen_US
dc.subjectCorden_US
dc.subjectInvolvementen_US
dc.subjectAnalgesiaen_US
dc.subjectPathwaysen_US
dc.titleContribution of spinal 5-HT5A receptors to the antinociceptive effects of systemically administered cannabinoid agonist WIN 55,212-2 and morphineen_US
dc.typeArticleen_US

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