Three new benzophenone glycosides with MAO-A inhibitory activity from Hypericum thasium Griseb.

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dc.contributor.authorDemirkiran, Ozlem
dc.date.accessioned2024-06-12T11:03:35Z
dc.date.available2024-06-12T11:03:35Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurification of n-BuOH fraction from 80% ethanol extract of Hypericum thasium Griseb. resulted in the isolation of three new compounds 3',4,5'-trihydroxy-6-methoxy-2-O-alpha-L-arabinosylbenzophenone (1), 3',4,5',6-tetrahydroxy-2-O-alpha-L-arabinosylbenzophenone (2), and 3',4-dihydroxy-5'-methoxy-2-O-alpha-L-arabinosyl-6-O-beta-D-xylosylbenzophenone (3) along with a known flavonoid glycoside quercetin-3-O-alpha-L-arabinofuranoside (4). The structures of the new compounds were elucidated by 1D and 2D NMR analysis as well as HRESIMS. The isolated compounds (1-4), as well as quercetin, and kaempferol previously isolated from EtOAc fraction were screened against MAO-A inhibitory activity. When tested against the MAO-A quercetin and kaempferol displayed IC50 values of 19.6, and 17.5 mu M, respectively. The IC50 values for MAO-A inhibition by compounds (1-4) were 310.3, 111.2, 726.0, and 534.1 mu M, respectively. Standard inhibitor (clorgyline) exhibited MAO-A inhibition with an IC50 value of 0.5 mu M. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.phytol.2012.06.018
dc.identifier.endpage704en_US
dc.identifier.issn1874-3900
dc.identifier.issn1876-7486
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84869500753en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage700en_US
dc.identifier.urihttps://doi.org/10.1016/j.phytol.2012.06.018
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21697
dc.identifier.volume5en_US
dc.identifier.wosWOS:000311337300003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofPhytochemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypericum Thasium Griseb.en_US
dc.subjectBenzophenone Glycosidesen_US
dc.subjectMAO-Aen_US
dc.subjectAntidepressantsen_US
dc.subjectSt-Johns-Worten_US
dc.subjectMonoamine-Oxidaseen_US
dc.subjectXanthonesen_US
dc.subjectIdentificationen_US
dc.subjectDepressionen_US
dc.subjectAssignmenten_US
dc.subjectQuercetinen_US
dc.subjectExtractsen_US
dc.subjectPlaceboen_US
dc.subjectNmren_US
dc.titleThree new benzophenone glycosides with MAO-A inhibitory activity from Hypericum thasium Griseb.en_US
dc.typeArticleen_US

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