The effect of royal jelly on CD3+, CD5+, CD45+ T-cell and CD68+ cell distribution in the colon of rats with acetic acid-induced colitis

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dc.authoridYörük, Mecit/0000-0001-6820-8105
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridKara, Adem/0000-0002-5766-6116
dc.authoridUslu, Sema/0000-0002-2239-7841
dc.authorwosidSimsek, Nejdet/B-4040-2008
dc.authorwosidkalkan, yildiray/B-8064-2015
dc.authorwosidcan, ismail/O-5461-2014
dc.authorwosidYörük, Mecit/AAG-4710-2019
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidUslu, Sema/JVP-3565-2024
dc.authorwosidKara, Adem/J-4911-2013
dc.contributor.authorKaraca, T.
dc.contributor.authorSimsek, N.
dc.contributor.authorUslu, S.
dc.contributor.authorKalkan, Y.
dc.contributor.authorCan, I.
dc.contributor.authorKara, A.
dc.contributor.authorYoruk, M.
dc.date.accessioned2024-06-12T10:58:05Z
dc.date.available2024-06-12T10:58:05Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Traditional medicines and health supplements have historically been used to treat many illnesses but most of them have not been evaluated objectively to prove their efficacy. We have been investigating the effects of royal jelly (RJ) supplements on acetic acid-induced colitis on the distribution of CD3(+), CD5(+), CD45(+) T-cell and CD68(+) cells in rats. Methods: The rats were divided into four equal groups: control group, royal jelly-treated (RJ - 150 mg kg(-1) body weight), acetic acid-treated (colitis) and acetic acid-treated (colitis) + royal jelly (CRJ - 150 mg kg(-1) body weight). Colitis was induced by intracolonic instillation of 4% acetic acid; the control group received physiological saline (10 mL kg(-1)). Colon samples were obtained under deep anaesthesia from animals in four groups. Tissues were fixed in 10% formalin neutral buffer solution for 24 h and embedded in paraffin. Results: The proliferative response of CD3(+) and CD45(+) T cells stimulated with colitis was affected by colitis treated with RJ. No differences were found in CD5(+) T cells and CD68(+) macrophages in the colitis treated with RJ. Conclusions: This study has shown that RJ has anti-inflammatory and cell regeneration effect in the colon of rats with acetic acid induced colitis. (c) 2011 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.en_US
dc.identifier.doi10.1016/j.aller.2011.09.004
dc.identifier.endpage361en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue6en_US
dc.identifier.pmid22115572en_US
dc.identifier.scopus2-s2.0-84869144937en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://doi.org/10.1016/j.aller.2011.09.004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19936
dc.identifier.volume40en_US
dc.identifier.wosWOS:000312047000007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofAllergologia Et Immunopathologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColitisen_US
dc.subjectRoyal Jellyen_US
dc.subjectLymphocytesen_US
dc.subjectMacrophagesen_US
dc.subjectRaten_US
dc.subjectPolyunsaturated Fatty-Acidsen_US
dc.subjectInflammatory-Bowel-Diseaseen_US
dc.subjectImmuneen_US
dc.subjectModulationen_US
dc.subjectCytokinesen_US
dc.subjectResponsesen_US
dc.subjectFibrosisen_US
dc.subjectStressen_US
dc.titleThe effect of royal jelly on CD3+, CD5+, CD45+ T-cell and CD68+ cell distribution in the colon of rats with acetic acid-induced colitisen_US
dc.typeArticleen_US

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