Levels of high-sensitivity C-reactive protein, leptin, and resistin in patients with overt hypothyroidism and subclinical hypothyroidism

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dc.contributor.authorGuldiken, Sibel
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorArikan, Ender
dc.contributor.authorAzcan, Sennur
dc.contributor.authorTugrul, Armagan
dc.date.accessioned2024-06-12T11:03:38Z
dc.date.available2024-06-12T11:03:38Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractHypothyroidism is associated with an increased risk for obesity and cardiovascular diseases. Resistin and leptin exert proinflammatory actions by activating a specific receptors which are expressed in human endothelial cells. The aim of the study was to investigate whether the relations between the leptin, resistin, and high-sensitivity C-reactive protein (hs-CRP), which is a marker of low-grade inflammation, in patients with subclinical (SH) and overt hypothyroidism (OH). The levels of leptin, resistin, and hs-CRP were measured in 25 patients with CH, 30 patients with SH, and in 25 healthy subjects, using enzyme-linked immunosorbent assay method. The leptin and resistin levels in patients with OH and SH were similar to those in the control group. The hs-CRP level in OH group was significantly higher than SH and control groups (P < 0.001, P < 0.001). In the OH group, hs-CRP levels were positively correlated with thyroid-stimulating hormone levels (P < 0.001, r = 0.728) and negatively correlated with fF4 levels (P = 0.01 r = -0.51). Combining the OH and SH groups, serum hs-CRP levels were significantly correlated with thyroid-stimulating hormone levels (P < 0.001, r = 0.765) and fr4 (P < 0.001, r = -0.716). No significant correlation was found between hs-CRP and leptin or resistin in patients with OH and SH. We suggest that the elevated hs-CRP levels in hypothyroidism may play a role in the increased risk for atherosclerosis in these patients.en_US
dc.identifier.doi10.1097/TEN.0b013e3181652c8d
dc.identifier.endpage33en_US
dc.identifier.issn1051-2144
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-40049104187en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage30en_US
dc.identifier.urihttps://doi.org/10.1097/TEN.0b013e3181652c8d
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21730
dc.identifier.volume18en_US
dc.identifier.wosWOS:000252939100010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEndocrinologisten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypothyroidismen_US
dc.subjectLeptinen_US
dc.subjectResistinen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectCardiovascular Risk-Factorsen_US
dc.subjectAdipose-Tissueen_US
dc.subjectMechanismsen_US
dc.subjectDiseaseen_US
dc.subjectInflammationen_US
dc.subjectDysfunctionen_US
dc.subjectExpressionen_US
dc.subjectObesityen_US
dc.titleLevels of high-sensitivity C-reactive protein, leptin, and resistin in patients with overt hypothyroidism and subclinical hypothyroidismen_US
dc.typeArticleen_US

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