Obstetric outcomes of recurrent pregnancy loss patients diagnosed with inherited thrombophilia

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dc.authoridYoldemir, Tevfik/0000-0001-6925-4154
dc.authorwosidYoldemir, Tevfik/AAA-3506-2019
dc.contributor.authorKaradag, C.
dc.contributor.authorYoldemir, T.
dc.contributor.authorKaradag, S. D.
dc.contributor.authorInan, C.
dc.contributor.authorDolgun, Z. N.
dc.contributor.authorAslanova, L.
dc.date.accessioned2024-06-12T11:13:26Z
dc.date.available2024-06-12T11:13:26Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies. The relation between RPL and inherited thrombophilia requires anticoagulant therapy during pregnancy. However the obstetric outcomes have not been well defined in these RPL patients diagnosed with inherited thrombophilia, who have been given anticoagulant therapy. Aim To investigate the obstetric outcomes in pregnant women with RPL who are given low molecular weight heparin (LMWH) and low-dose aspirin due to diagnosis of inherited thrombophilia. Methods A hundred and eight RPL women were diagnosed with inherited thrombophilia, and 98 women were diagnosed with unexplained RPL. The patients with inherited thrombophilia were given LMWH and low-dose aspirin. Unexplained RPL patients were not given any medicine. The obstetric outcomes of participants were noted. Results In thrombophilic group, the live-birth levels were significantly higher [90 (83%) vs 67 (68%) p < 0.05], and the miscarriage levels were significantly lower than that in the control group [14 (13%) vs 27 (28%) p < 0.01]. The number of patients with preeclampsia was significantly higher in the thrombophilic group [16 (15%) vs 6 (6%) p < 0.05]. The number of preterm births was significantly higher than that of the controls [25 (23%) vs 10 (10%) p < 0.05]. The median gestation age of delivery was 35 weeks for thrombophilic patients and 38 weeks for controls (p < 0.05). Conclusion The RPL patients diagnosed with inherited thrombophilia and who were given LMWH with low-dose aspirin had higher live-birth rates and lower miscarriage rates than those in the unexplained RPL patients. Increased risk of preeclampsia is seen in RPL patients with inherited thrombophilia despite thrombophilia prophylaxis.en_US
dc.identifier.doi10.1007/s11845-017-1569-0
dc.identifier.endpage713en_US
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue3en_US
dc.identifier.pmid28176193en_US
dc.identifier.scopus2-s2.0-85011887540en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage707en_US
dc.identifier.urihttps://doi.org/10.1007/s11845-017-1569-0
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23556
dc.identifier.volume186en_US
dc.identifier.wosWOS:000407372800026en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofIrish Journal Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRecurrent Pregnancy Lossen_US
dc.subjectInherited Thrombophiliaen_US
dc.subjectLow Molecular Weight Heparinen_US
dc.subjectPreeclampsiaen_US
dc.subjectAspirinen_US
dc.subjectMolecular-Weight Heparinen_US
dc.subjectFactor-V-Leidenen_US
dc.subjectRisk-Factorsen_US
dc.subjectFetal Lossen_US
dc.subjectWomenen_US
dc.subjectPreeclampsiaen_US
dc.subjectComplicationsen_US
dc.subjectAssociationen_US
dc.subjectMetaanalysisen_US
dc.subjectProthrombinen_US
dc.titleObstetric outcomes of recurrent pregnancy loss patients diagnosed with inherited thrombophiliaen_US
dc.typeArticleen_US

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