Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury

Basit Öğe Kaydı
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridugurel, vedat/0000-0002-1307-4688
dc.authorwosiddemirtaş, selim/JED-6784-2023
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidÇİÇEK, Ayşegül ÇOPUR/AAM-6146-2021
dc.contributor.authorUgurel, Vedat
dc.contributor.authorCicek, Ahmet Cagatay
dc.contributor.authorCemek, Mustafa
dc.contributor.authorDemirtas, Selim
dc.contributor.authorKocaman, A. Tuba
dc.contributor.authorKaraca, Turan
dc.date.accessioned2024-06-12T10:52:09Z
dc.date.available2024-06-12T10:52:09Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective(s): To evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion-detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (IR) injury. Materials and Methods: Eighteen female Wistar albino rats were used in control, IR, and IR+Edosteine (IR-E) groups, (n=6 in each). The IR-E group received the erdosteine for seven days before the induction of torsion/retorsion, (10 mg/kg/days). The IR and IR-E groups were exposed to right unilateral adnexal torsion for 3 hr. Three hours later, re-laparotomy was performed, and the right ovaries were surgically excised. Oxidant and antioxidants levels were determined in serum. The ovarian tissue samples were received and fixed with 10% neutral buffered formalin. The sections were stained with H&E, anti-PCNA, and TUNEL. Results: The IR group were showed severe acute inflammation, polynuclear leukocytes and macrophages, stromal oedema and haemorrhage. Treatment with erdosteine in rats significantly retained degenerative changes in the ovary PCNA (+) cell numbers were significantly decreased in the IR and IR-E groups unlike the control group. However, its numbers were significantly increased in the IR-E group unlike the IR group. TUNEL (+) cell numbers were significantly increased in the IR group unlike the control and the IR-E groups. In erdosteine treated group, TUNEL (+) cells were detected significantly less than the IR group (P<0.05). Conclusion: In conclusion, erdosteine maybe a protective agent for ovarian damage and decreasing lipid peroxidation products and leukocytes aggregation after adnexal torsion in animals.en_US
dc.identifier.doi10.22038/ijbms.2017.8093
dc.identifier.endpage58en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue1en_US
dc.identifier.pmid28133525en_US
dc.identifier.scopus2-s2.0-85008198087en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.22038/ijbms.2017.8093
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18590
dc.identifier.volume20en_US
dc.identifier.wosWOS:000391090500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectErdosteineen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectOxidanten_US
dc.subjectOvaryen_US
dc.subjectRaten_US
dc.subjectVitamin-Een_US
dc.subjectHind-Limbsen_US
dc.subjectCombinationen_US
dc.subjectApoptosisen_US
dc.subjectDamageen_US
dc.titleAntioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injuryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu