Is lymph node dissection necessary for staging while undergoing nephrectomy in patients with renal cell carcinoma?

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dc.authoridDEMİR, TARIK/0000-0001-6334-4079
dc.authoridERSOZ, CEVPER/0000-0001-5508-9370
dc.authoridBeşiroğlu, Mehmet/0000-0002-1171-8320
dc.authoridAraz, Murat/0000-0002-4632-9501
dc.authoridSAKIN, Abdullah/0000-0003-2538-8569
dc.authoridAliyev, Altay/0000-0002-2024-7751
dc.authorwosidDEMİR, TARIK/AAA-5670-2020
dc.authorwosidERSOZ, CEVPER/T-3308-2018
dc.authorwosidBeşiroğlu, Mehmet/AEQ-3080-2022
dc.authorwosidAraz, Murat/C-6388-2015
dc.authorwosidAliyev, Altay/JVY-9357-2024
dc.contributor.authorDemir, Tarik
dc.contributor.authorAliyev, Altay
dc.contributor.authorBesiroglu, Mehmet
dc.contributor.authorAraz, Murat
dc.contributor.authorKostek, Osman
dc.contributor.authorSakin, Abdullah
dc.contributor.authorShbair, Abdallah T. M.
dc.date.accessioned2024-06-12T10:51:05Z
dc.date.available2024-06-12T10:51:05Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The essential treatment for patients with renal cell carcinoma is nephrectomy. As no lymph node dissection (LND) could be performed in the majority of these patients, healthy staging could not be carried out. In this study, we investigated the impact of LND during nephrectomy on patient survival. Methods: A total of 181 patients-58 (32%) were female and 123 (68%) were male-were included in the study. Median follow-up period was 48 months. The patients were separated into 4 groups according to their stage during diagnosis; group 1 (T1-3N0M0), group 2 (T1-3NXM0), group 3 (T1-3N1M0), and group 4 (T14N0/XM1). The disease-free survival of nonmetastatic patients and the overall survival of all groups were calculated. Results: Mean age was 58.4 +/- 12.0 years. Median survival for Group 1 could not be reached. Median survival was 89 months in Group 2, 50 months in Group 3, and 39 months in Group 4 (P <0.001). There was no statistically significant difference between the N1 and M1 groups (P = 0.297). For the NX patient group without LND, median survival was 89 months, which is worse than the N0 group and better than the N1 group (P = 0.002). Conclusions: Our study presumes that the patients without LND are not staged sufficiently, NX patients have worse survival rates when compared with N0 patients, node-positive patients have poor survival rates as do the metastatic patients, and it should be defined as TNM stage4. (c) 2020 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.currproblcancer.2020.100619
dc.identifier.issn0147-0272
dc.identifier.issn1535-6345
dc.identifier.issue1en_US
dc.identifier.pmid32800688en_US
dc.identifier.scopus2-s2.0-85089452388en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.currproblcancer.2020.100619
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18239
dc.identifier.volume45en_US
dc.identifier.wosWOS:000659811700012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofCurrent Problems In Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAJCC Staging Systemen_US
dc.subjectLymph Node Dissectionen_US
dc.subjectLymph Node Metastasisen_US
dc.subjectNephrectomyen_US
dc.subjectRenal Cell Carcinomaen_US
dc.subjectRadical Nephrectomyen_US
dc.subjectInvolvementen_US
dc.titleIs lymph node dissection necessary for staging while undergoing nephrectomy in patients with renal cell carcinoma?en_US
dc.typeArticleen_US

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