Scintigraphic evaluation of small intestinal transit in the streptozotocin induced diabetic rats

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridvardar, selma arzu/0000-0002-1073-1718
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.contributor.authorDurmus-Altun, G.
dc.contributor.authorVatansever, U.
dc.contributor.authorArzu, Vardar S.
dc.contributor.authorAltaner, S.
dc.contributor.authorDirlik, B.
dc.date.accessioned2024-06-12T11:14:15Z
dc.date.available2024-06-12T11:14:15Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: Small intestine (SI) transit in the streptozotocin (STZ) induced diabetic rats were examined by using 99mTc-mebrofenin scintigraphy. Materials and methods: Wistar albino rats (mean body weight: 220 +/- 12 g) were studied for both control (n=10) and diabetes mellitus (DM) (n=10) groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin (50 mg kg(-1) body weight. SI transit time was assessed by measuring arrival times of 99mTc-mebrofenin from duodenum to caecum. Results: The mean transit time of 99mTc-mebrofenin was 67.8 +/- 11 min in control group. The mean transit time of SI was prolonged in STZ induced diabetic animals with (111.9 +/- 12.5, p=0.01). There was significant correlation between small intestinal transit time and blood glucose level (r: 0.73, p=0.01). Conclusion: We observed that SI transit was prolonged in diabetic animals using 99mTc-mebrofenin, and additionally this technique is a readily available method for the detection of transit abnormalities in animal experiment. Hippokratia 2011; 15 (3): 262-264en_US
dc.identifier.endpage264en_US
dc.identifier.issn1108-4189
dc.identifier.issue3en_US
dc.identifier.pmid22435026en_US
dc.identifier.scopus2-s2.0-79959821929en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage262en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23869
dc.identifier.volume15en_US
dc.identifier.wosWOS:000293229100012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLithographiaen_US
dc.relation.ispartofHippokratiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSmall Intestineen_US
dc.subjectScintigraphyen_US
dc.subject99mtc-Mebrofeninen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectStreptozotocinen_US
dc.subjectConcise Communicationen_US
dc.subjectSmall-Bowelen_US
dc.subjectSymptomsen_US
dc.subjectMellitusen_US
dc.subjectInvitroen_US
dc.subjectInjuryen_US
dc.subjectHidaen_US
dc.titleScintigraphic evaluation of small intestinal transit in the streptozotocin induced diabetic ratsen_US
dc.typeArticleen_US

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