Placental and serum levels of human Klotho in severe preeclampsia: A potential sensitive biomarker

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dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authoridEKER, DAMLA/0000-0001-7563-118X
dc.authorwosideker, damla/AAE-6947-2020
dc.authorwosidATLI, Engin/AAY-4641-2021
dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.contributor.authorCilingir, Isil Uzun
dc.contributor.authorVarol, Fusun
dc.contributor.authorGurkan, Hakan
dc.contributor.authorSutcu, Havva
dc.contributor.authorAtli, Engin
dc.contributor.authorEker, Damla
dc.contributor.authorInan, Cihan
dc.date.accessioned2024-06-12T11:03:23Z
dc.date.available2024-06-12T11:03:23Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: The Klotho (KL) gene, initially defined as an anti-aging gene in mice, shares 86% of the amino acid sequence withthe human KL protein. The KL gene plays roles in endothelial nitric oxide production, angiogenesis, antioxidant enzyme production and protecting against endothelial dysfunction, all of which may be associated with preeclampsia (PE). Human KL is the precursor of the gene products: alpha-KL and beta-KL. In this study, we evaluated the gene expression, serum and placental levels of human KL in women with severe PE, pregnant women with chronic hypertension and healthy pregnant controls. Also, the gene expression, serum and placental levels of human decorin (DCN) were evaluated. Methods: A total of 36 patients with severe PE, 10 with chronic hypertension, and 28 with healthy controls were enrolled. Placental and serum levels together with of KL and DCN were measured by ELISA and alsogene expression of these were evaluated. Results: Placental and serum KL levels were significantly higher in the PE than in the controls and in women with chronic hypertension. Serum DCN levels were significantly higher in the PE women compared to controls and pregnant women with chronic hypertension. Placental DCN was similar in PE and healthy controls. There was no significant difference in the gene expression of KL and DCN in the groups. The best cut-off level for human KL to identify the presence of PE was calculated as 12.48 pg/ml with a sensitivity of 100% and and specificity of 96%, whereas for DCN 62.33 ng/ml to assess the presence of PE with a sensitivity of 86.1% and a specificity of 88%. Conclusion: Human KL may be a valuable marker for PE, with high sensitivity and specificity. It also appears to be more sensitive and specific than human DCN.en_US
dc.description.sponsorshipTrakyaUniversity (Scientific Research Projects of Trakya University Medical Faculty) [2017-208]en_US
dc.description.sponsorshipThe study was supported by a Grant from TrakyaUniversity (Scientific Research Projects of Trakya University Medical Faculty) (2017-208).en_US
dc.identifier.doi10.1016/j.placenta.2019.08.084
dc.identifier.endpage55en_US
dc.identifier.issn0143-4004
dc.identifier.issn1532-3102
dc.identifier.pmid31446221en_US
dc.identifier.scopus2-s2.0-85070932269en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://doi.org/10.1016/j.placenta.2019.08.084
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21638
dc.identifier.volume85en_US
dc.identifier.wosWOS:000484393600007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofPlacentaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHuman Klothoen_US
dc.subjectPreeclampsiaen_US
dc.subjectGene Expressionen_US
dc.subjectDecorinen_US
dc.subjectPlacental Levelsen_US
dc.subjectAlpha-Klothoen_US
dc.subjectPregnancyen_US
dc.subjectProteinen_US
dc.subjectGeneen_US
dc.titlePlacental and serum levels of human Klotho in severe preeclampsia: A potential sensitive biomarkeren_US
dc.typeArticleen_US

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