Can radiation-induced chronic oxidative stress in kidney and liver be prevented by dimethylsulfoxide? Biochemical determination by serum and tissue markers

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dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidIbis, Kamuran/AAD-1939-2019
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.contributor.authorCosar, R.
dc.contributor.authorEskiocak, S.
dc.contributor.authorCaloglu, V. Yurut
dc.contributor.authorOzen, A.
dc.contributor.authorUzal, C.
dc.contributor.authorCaloglu, M.
dc.contributor.authorIbis, K.
dc.date.accessioned2024-06-12T10:52:09Z
dc.date.available2024-06-12T10:52:09Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To investigate the protective effects of dimethylsulfoxide (DMSO) on chronic oxidative stress in the liver, kidney and serum with biochemical parameters such as malondialdehyde (MDA), advanced oxidation protein product (AOPP), catalase, glutathione (GSH), and free-thiols (F-SW. Methods: Thirty Wistar albino female rats were randomly divided into 3 groups: group [(control, n=10), group H (irradiation-alone group, n=10) and group III (DMSO and irradiation group, n=10). Rats in groups II and III were irradiated with a single dose of 6 Gy to the entire liver and right kidney. Group III received DMSO 4.5 g/kg by intraperitoneal injection 30 min before irradiation. At the end of the 24th week, the rats were sacrificed and their trunk blood, kidney and liver tissues were collected. Results: Group II rats showed increased levels of lipid peroxidation and protein oxidation, with decreased GSH, F-SH and catalase levels in all specimens when compared with group I. Serum and kidney MDA and AOPP levels were significantly lower in group III when compared with group II. However, serum and kidney GSH and F-SH levels were significantly higher in group III when compared with group II. The additive effect on catalase was seen only in the serum. Conclusion: DMSO is a protective agent on chronic oxidative stress in the serum and kidney tissue. No oxidant or antioxidant effect of DMSO in the liver was seen.en_US
dc.identifier.endpage167en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue1en_US
dc.identifier.pmid22517712en_US
dc.identifier.scopus2-s2.0-84859826951en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage160en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18596
dc.identifier.volume17en_US
dc.identifier.wosWOS:000302503700027en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal Of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidative Markersen_US
dc.subjectDimethylsulfoxideen_US
dc.subjectOxidative Markersen_US
dc.subjectRadiation-Induced Oxidative Stressen_US
dc.subjectDimethyl-Sulfoxideen_US
dc.subjectProtein Productsen_US
dc.subjectGlutathioneen_US
dc.subjectMechanismen_US
dc.titleCan radiation-induced chronic oxidative stress in kidney and liver be prevented by dimethylsulfoxide? Biochemical determination by serum and tissue markersen_US
dc.typeArticleen_US

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