Experimental myoglobinuric acute renal failure: The effect of vitamin C

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.contributor.authorUstundag, Sedat
dc.contributor.authorYalcin, Omer
dc.contributor.authorSen, Saniye
dc.contributor.authorCukur, Ziya
dc.contributor.authorCiftci, Senturk
dc.contributor.authorDemirkan, Bora
dc.date.accessioned2024-06-12T11:13:39Z
dc.date.available2024-06-12T11:13:39Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractDuring times of war and natural disasters, rhabdomyolysis-induced myoglobinuric acute renal failure (ARF) can assume epidemic proportions. Free radicals play an important role in the pathogenesis of myoglobinuric ARF. Vitamin C is a major antioxidant, scavenging free radicals. We have not found any studies on the effect of vitamin C on myoglobinuric ARF. Thus, we aimed to investigate the effects of vitamin C on the myoglobinuric ARF formed by glycerol in rats. Three groups of rats were employed in this study. Group 1 served as control, group 2 was given 50% glycerol (10 mL/kg, i.m.), and group 3 was given glycerol plus vitamin C (20 mg/kg, i.p. for four days). Ninety-six hours after glycerol injections, blood samples and kidney tissues were taken from the anesthetized rats. Urea and creatinine levels in plasma; N-acetyl-beta-D-glucosaminidase activity in urine; malondialdehyde levels, superoxide dismutase and catalase enzyme activity in kidney tissue were determined. Histopathological changes and iron accumulation in the kidney tissue were evaluated. In this study, glycerol administration led to marked renal oxidative stress and severe renal functional and morphological deterioration. The treatment of animals with vitamin C partially corrected the renal dysfunction and morphological impairment. In this respect, vitamin C appears to be a promising candidate for the prevention of rhabdomyolysis-induced ARF. Higher dosages of vitamin C than in 20 mg/kg may be beneficial for better functional and morphological recovery in this model ARF.en_US
dc.description.sponsorshipTrakya University, Scientific Researchs Committee [TUBAB-501]en_US
dc.description.sponsorshipThis work was supported by Trakya University, Scientific Researchs Committee (project TUBAB-501).en_US
dc.identifier.doi10.1080/08860220802212965
dc.identifier.endpage735en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue7en_US
dc.identifier.pmid18704822en_US
dc.identifier.scopus2-s2.0-49649120171en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage727en_US
dc.identifier.urihttps://doi.org/10.1080/08860220802212965
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23632
dc.identifier.volume30en_US
dc.identifier.wosWOS:000258451500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRhabdomyolysisen_US
dc.subjectMyoglobinuric Acute Renal Failureen_US
dc.subjectVitamin Cen_US
dc.subjectFree Radicalsen_US
dc.subjectOxidative Stressen_US
dc.subjectLow-Density-Lipoproteinen_US
dc.subjectAscorbic-Aciden_US
dc.subjectInduced Nephrotoxicityen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectFree-Radicalsen_US
dc.subjectIronen_US
dc.subjectAntioxidanten_US
dc.subjectRhabdomyolysisen_US
dc.subjectOxidationen_US
dc.subjectSupplementationen_US
dc.titleExperimental myoglobinuric acute renal failure: The effect of vitamin Cen_US
dc.typeArticleen_US

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