Frequent oral ulceration during early disease may predict a severe disease course in males with Behcet's syndrome

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dc.authoridHatemi, Gulen/0000-0002-1952-1135
dc.authoridHamuryudan, Vedat/0000-0001-6625-1652
dc.authoridUgurlu, serdal/0000-0002-9561-2282
dc.authorwosidUgurlu, Serdal/AAD-6039-2020
dc.authorwosidHatemi, Gulen/AAC-9647-2021
dc.authorwosidHatemi, Gulen/AFM-7014-2022
dc.authorwosidHamuryudan, Vedat/AAA-1100-2020
dc.authorwosidYurdakul, Sebahattin/M-6927-2013
dc.authorwosidYURDAKUL, SEBAHATTİN/AAY-1069-2020
dc.contributor.authorHamuryudan, V.
dc.contributor.authorHatemi, G.
dc.contributor.authorSut, N.
dc.contributor.authorUgurlu, S.
dc.contributor.authorYurdakul, S.
dc.contributor.authorYazici, H.
dc.date.accessioned2024-06-12T10:54:21Z
dc.date.available2024-06-12T10:54:21Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective. The numbers and recurrence rates of mucocutaneous manifestations can be highly variable among patients with Behcet's syndrome (BS) but it is not known whether these differences influence the disease course at the long-term. Methods. We evaluated the outcome of 30 patients that made up the placebo arm of a 6 months controlled trial of thalidomide and looked at the relation between the frequencies of mucocutaneous manifestations during the trial and the development of major organ involvement necessitating immunosuppressives during the post-trial period. Results. Fifteen (50%) patients had received immunosuppresives for major organ involvement during the post-trial period. Patients receiving immunosuppressive treatment were significantly younger at the onset of BS compared to those who did not (24.5 +/- 5 vs. 29.7 +/- 3.8 SD years; p=0.003). The mean number of oral ulcers recorded throughout the trial was significantly higher among patients using immunosuppressives compared to those who did not (2.09 +/- 0.96 vs. 1.43 +/- 0.8; p=0.029). This significance disappeared when adjusted for age of onset of BS (p=0.16). ROC curve analysis showed that having 10 or more ulcers during 6 months has a sensitivity of 86.7% and a specificity of 53% for the subsequent necessity of immunosuppressive use. The same association was not true for genital ulcers, follicular lesions and erythema nodosum. Conclusion. These findings on a limited number of patients suggest that frequent occurrence of oral ulceration during the initial years of the disease may predict the development of major organ involvement in men with BS.en_US
dc.identifier.endpageS34en_US
dc.identifier.issn0392-856X
dc.identifier.issue3en_US
dc.identifier.pmid22935508en_US
dc.identifier.startpageS32en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19010
dc.identifier.volume30en_US
dc.identifier.wosWOS:000314619000007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClinical & Exper Rheumatologyen_US
dc.relation.ispartofClinical And Experimental Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's Diseaseen_US
dc.subjectOral Ulcersen_US
dc.subjectMajor Organ Involvementen_US
dc.subjectOutcomeen_US
dc.subjectPrognosisen_US
dc.subjectRecurrent Aphthous Stomatitisen_US
dc.subjectClinical-Featuresen_US
dc.subjectControlled-Trialen_US
dc.subjectManifestationsen_US
dc.subjectPrognosisen_US
dc.subjectOnseten_US
dc.titleFrequent oral ulceration during early disease may predict a severe disease course in males with Behcet's syndromeen_US
dc.typeArticleen_US

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