The Role of 68Ga PSMA Imaging in Evaluating Adrenal Lesions in Prostate Cancer Patients

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dc.contributor.authorUstun, Funda
dc.contributor.authorGunay, Busra Ozdemir
dc.contributor.authorUstabasioglu, Fethi Emre
dc.contributor.authorKorkmaz, Selcuk
dc.date.accessioned2024-06-12T10:50:47Z
dc.date.available2024-06-12T10:50:47Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives Gallium-68 prostate-specific membrane antigen (Ga-68-PSMA) imaging is valuable for staging because an accurate diagnosis, metastatic or nonmetastatic for prostate cancer patients, is required for deciding to treatment approaches and prognostic assessment. The aim of this study was primarily to distinguish between benign and metastatic adrenal gland lesions detected during Ga-68-PSMA positron emission tomography (PET)/CT imaging, to evaluate the presence of factors predicting its development, and then to determine the life expectancy of patients with metastatic adrenal lesions. Materials and Methods We performed a database search for PET/CT records generated from June 2016 to February 2021 for adrenal gland in report for patients who underwent Ga-68-PSMA examination with prostate cancer patients. Results Twenty-three patients (10 benign and 13 metastatic) were included in this study. The total prostate-specific antigen, adrenal gland size, adrenal gland density, and maximum standardized uptake (SUVmax) values are significantly different between groups (p < 0.05). On receiver operating characteristic curve analysis, the SUVmax cutoff value > 6.8 provided both sensitivity and specificity of 100%. However, with 29 mm as the adrenal gland size cutoff and 21.2 as Hounsfield unit, the sensitivity and specificity were 56.2 and 92.3%, and 93.8 and 92.3%, respectively. The survival of the benign and metastatic groups was compared and a statistically significant difference was found (p = 0.006). The presence of pelvic lymph nodes was statistically negatively affected the surveillance between the groups. Conclusion The presence of atypical metastases such as adrenal gland is not insignificant in prostate cancer patients. Because of this degree of impact on patient management, accurate staging by imaging with Ga-68-PSMA should be an integral part of prostate cancer management.en_US
dc.identifier.doi10.1055/s-0044-1786012
dc.identifier.issn1450-1147
dc.identifier.issn1607-3312
dc.identifier.urihttps://doi.org/10.1055/s-0044-1786012
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18127
dc.identifier.wosWOS:001206634100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherThieme Medical Publ Incen_US
dc.relation.ispartofWorld Journal Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdrenal Gland Metastasesen_US
dc.subjectGa-68-PSMAen_US
dc.subjectProstate Canceren_US
dc.subjectBenign Adrenal Glanden_US
dc.subjectSurvivalen_US
dc.subjectMetastatic Patternsen_US
dc.subjectExperienceen_US
dc.subjectAutopsyen_US
dc.subjectSiteen_US
dc.titleThe Role of 68Ga PSMA Imaging in Evaluating Adrenal Lesions in Prostate Cancer Patientsen_US
dc.typeArticleen_US

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