Assessment of biological and clinical aggressiveness of invasive ductal breast cancer using baseline 18F-FDG PET/CT-derived volumetric parameters

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dc.authoridAktas, Gul Ege/0000-0003-4880-2275
dc.authorwosidAktas, Gul Ege/R-1776-2019
dc.contributor.authorAktas, Gul Ege
dc.contributor.authorTastekin, Ebru
dc.contributor.authorSarikaya, Ali
dc.date.accessioned2024-06-12T10:55:11Z
dc.date.available2024-06-12T10:55:11Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectiveThe aim of this study was to evaluate the relationship of baseline fluorine-18-fluorodeoxyglucose PET/computed tomography (CT)-derived volumetric parameters for the primary tumor with clinicopathological risk factors and molecular subtypes in patients with invasive ductal breast carcinoma (IDBC).Patients and methodsWe evaluated 65 patients who underwent fluorine-18-fluorodeoxyglucose PET/CT for initial breast cancer staging. The association of maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume, and total lesion glycolysis (TLG) with clinicopathological risk factors and molecular subtypes was investigated and the discriminative power of significant features was assessed.ResultsAll volumetric parameters were significantly higher for tumors measuring more than 2cm and with a Ki-67 index of at least 20. Estrogen receptor (ER) and progesterone receptor (PR)-negative (ER-/PR-), human epidermal growth factor receptor 2-positive (HER2+), and triple-negative tumors showed increased SUVmax. SUVmax and SUVmean were higher for triple-negative and HER2+ IDBC than for ER+/HER2- IDBC. Metabolic tumor volume and TLG showed no differences among subtypes. All volumetric parameters correlated with the clinical tumor size and the Ki-67 index; these correlations differed among the different subtypes. Patients with systemic metastases showed significantly higher TLG. Receiver operating characteristic analysis showed that SUVmax had the highest discriminative power for the different subtypes, whereas TLG had a statistically significant discriminative power for systemic metastasis.ConclusionSUV(max) may appropriately reflect the immunohistochemical characteristics of IDBC, whereas TLG is associated with clinical risk factors and systemic metastasis. Our preliminary findings suggesting different relationships between volumetric parameters and the clinical tumor size and the Ki-67 index for different subtypes require further evaluation.en_US
dc.identifier.doi10.1097/MNM.0000000000000779
dc.identifier.endpage93en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue1en_US
dc.identifier.pmid29135722en_US
dc.identifier.scopus2-s2.0-85038243547en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://doi.org/10.1097/MNM.0000000000000779
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19328
dc.identifier.volume39en_US
dc.identifier.wosWOS:000418141800013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectComputed Tomographyen_US
dc.subjectMetabolic Tumor Volumeen_US
dc.subjectMetastasisen_US
dc.subjectPETen_US
dc.subjectStandardized Uptake Valueen_US
dc.subjectTNM Stagingen_US
dc.subjectTotal Lesion Glycolysisen_US
dc.subjectMetabolic Tumor Volumeen_US
dc.subjectStandardized Uptake Valueen_US
dc.subjectTotal Lesion Glycolysisen_US
dc.subjectLobular Carcinomaen_US
dc.subjectClinicopathological Factorsen_US
dc.subjectNeoadjuvant Chemotherapyen_US
dc.subjectPrognostic-Factorsen_US
dc.subjectFdg Uptakeen_US
dc.subjectMetastasisen_US
dc.subjectFluorodeoxyglucoseen_US
dc.titleAssessment of biological and clinical aggressiveness of invasive ductal breast cancer using baseline 18F-FDG PET/CT-derived volumetric parametersen_US
dc.typeArticleen_US

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