Tissue damage in rat ovaries subjected to torsion and detorsion

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dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridPuyan, Fulya/0000-0001-5853-0109;
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorUsta, Ufuk
dc.contributor.authorInan, Mustafa
dc.contributor.authorErbas, Hakan
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorPuyan, Fulya Oz
dc.contributor.authorAltaner, Semsi
dc.date.accessioned2024-06-12T11:11:52Z
dc.date.available2024-06-12T11:11:52Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description21st European Congress of Pathology -- SEP 08-13, 2007 -- Istanbul, TURKEYen_US
dc.description.abstractWe aimed to evaluate histopathological changes, to detect HIF-1 alpha staining intensities and to determine MDA levels in rat ovaries, which were subjected to torsion and detorsion and treated with L-carnitine or N-acetyl cysteine (NAC). Forty-eight prepubertal female Sprague-Dawley rats were divided into five groups (n = 8): 1, control; 2, ischemia; 3, reperfusion; 4, L-carnitine; and 5, NAC groups. In groups 3, 4 and 5, an ischemic period of 3 h was followed by reperfusion for 24 h. In groups 4 and 5, ischemia was performed and either L-carnitine or NAC was infused intraperitoneally 30 min before reperfusion. Ovarian tissues were examined histopathologically; tissue MDA levels and serum IL-6 levels were determined biochemically. HIF-1 alpha was applied to all ovaries immunohistochemically. Total tissue damage scores, tissue MDA levels and HIF-1 alpha scores, were significantly higher in group 2 (all P < 0.001) than group 4, and group 3 than group 4 (P < 0.001, P = 0.05 and P < 0.001, respectively). They were also significantly higher in group 2 (all P < 0.001) than group 5. When group 3 is compared to group 5, total tissue damage scores and tissue MDA levels were significantly higher in the former (P < 0.01 and P < 0.001, respectively). Serum IL-6 levels were significantly higher in group 2 when compared to groups 1, 4 and 5 (all P < 0.01). The degree of tissue damage of the torsioned ovaries decreased after a reperfusion period of 24 h in the torsioned ovaries. However, ovaries of both L-carnitine and NAC groups showed better recovery than the reperfusion group.en_US
dc.description.sponsorshipEuropean Soc Patholen_US
dc.identifier.doi10.1007/s00383-008-2123-y
dc.identifier.endpage573en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue5en_US
dc.identifier.pmid18357459en_US
dc.identifier.scopus2-s2.0-42149119471en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage567en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-008-2123-y
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22964
dc.identifier.volume24en_US
dc.identifier.wosWOS:000254906000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOvaryen_US
dc.subjectIschemia And Reperfusionen_US
dc.subjectHistopathologyen_US
dc.subjectL-Carnitineen_US
dc.subjectN-Acetyl Cysteineen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectHypoxia-Inducible Factor-1-Alphaen_US
dc.subjectMyocardial-Ischemiaen_US
dc.subjectAcetylcysteineen_US
dc.subjectExpressionen_US
dc.subjectProtectsen_US
dc.subjectMarkersen_US
dc.titleTissue damage in rat ovaries subjected to torsion and detorsionen_US
dc.typeConference Objecten_US

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