Healthcare-Associated Neisseria meningitidis W135 Conjunctivitis

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dc.contributor.authorUnal Yilmaz, Gulizar
dc.contributor.authorAlkan, Metin
dc.contributor.authorVatansever Ozbek, Ulfet
dc.contributor.authorTugrul, H. Murat
dc.date.accessioned2024-06-12T11:09:03Z
dc.date.available2024-06-12T11:09:03Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNeisseria meningitidis is an unusual pathogen among the causes of acute bacterial conjunctivitis. Meningococcal conjunctivitis may present as primary or secondary infection, while primary meningococcal conjunctivitis may emerge as invasive or non-invasive forms. N.meningitidis W135 strain is not common in Turkey, and is rarely reported as the cause of meningitis. Moreover, no cases of conjunctivitis due to N.meningitidis W135 were reported from Turkey. In this report a case of N.meningitidis W135 conjunctivitis has been presented who acquired the infection from another patient with meningococcal meningitis by close contact in the hospital environment. A 2-month-old male infant was admitted to our hospital with poor health condition, feeding difficulty and weight loss. He was hospitalized in intensive care unit and fluid replacement started due to severe dehydration. The infant had stigmata of Down's Syndrome, and since conjunctivitis were detected on physical examination, swab samples were obtained from both eyes for direct microscopic examination and cultivation. Abundant lekocytes and gram-negative diplococci were observed in Gram-stained smears, and bacterial growth were detected in the culture from left eye samples. The isolate have been identified as N.meningitidis by conventional microbiological methods, and serotyping of the isolate yielded W135 strain. The infant was treated with systemic cefotaxime and ampicillin-sulbactam, together with topical tobramycin and gentamycin. Since no symptoms of meningitis appeared during the follow-ups, the case was diagnosed as non-invasive primary meningococcal conjunctivitis. Investigation for a probable source revealed that the infant had close contact with a six-year-old boy with high fever, unconsciousness and vomiting a week ago in the outpatient clinic of Tekirdag State Hospital. N.meningitidis was also isolated from the cerebrospinal fluid culture of probable index case with meningitis and identified as W135 strain by serotyping. Both strains isolated from these cases were found similar according to their phenotypical characteristics, however genotyping could not be performed. Since no other sources of exposure could be found, it was concluded that the infant with conjunctivitis acquired the bacteria from the other patient during their shared hospital visit. This patient is the first N.meningitidis W135 conjunctivitis case reported from Turkey.en_US
dc.identifier.endpage726en_US
dc.identifier.issn0374-9096
dc.identifier.issue4en_US
dc.identifier.pmid24237442en_US
dc.identifier.scopus2-s2.0-84890370538en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage722en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22670
dc.identifier.volume47en_US
dc.identifier.wosWOS:000328010300017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeisseria Meningitidis W135en_US
dc.subjectConjunctivitisen_US
dc.subjectHealthcare-Associated Infectionen_US
dc.subjectPrimary Meningococcal Conjunctivitisen_US
dc.titleHealthcare-Associated Neisseria meningitidis W135 Conjunctivitisen_US
dc.typeArticleen_US

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