Anti-Inflammatory and Antipruritic Effects of Remote Ischaemic Postconditioning in a Mouse Model of Experimental Allergic Contact Dermatitis

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dc.authoridKaya, Oktay/0000-0001-9639-8022
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.authorwosidKaya, Oktay/JGL-9169-2023
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorSapmaz-Metin, Melike
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorKaya, Oktay
dc.contributor.authorKaradag, Cetin Hakan
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:51:13Z
dc.date.available2024-06-12T10:51:13Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and Objectives: Allergic contact dermatitis is a common type IV hypersensitivity reaction characterised by redness, itching, oedema and thickening of the skin. It occurs in about 7% of the population and its incidence is increasing. It has been observed that the preconditioning of tissues by exposing them to transient ischemia increases resistance to subsequent permanent ischemia, and this phenomenon is called ischemic preconditioning. It has been shown that conditioning in one organ can also protect other organs. The protective effect of remote ischemic preconditioning is thought to be based on the induction of anti-inflammatory responses. The aim of this project was to investigate the anti-inflammatory and antipruritic effects of remote ischemic postconditioning in a mouse model of experimental allergic contact dermatitis. Methods: Experimental allergic contact dermatitis was induced with 1-fluoro-2,4-dinitrobenzene. Remote ischemic postconditioning was performed at 3 and 25 h after the challenge. Ear thickness and number of scratches 24 and 48 h after challenge, as well as cytokine levels and the infiltration of mast cells, neutrophils, CD4(+) and CD8(+ )T lymphocytes in serum and ear tissue at 48 h were measured to determine the effect of RIPsC. Results: Remote ischemic postconditioning decreased ear thickness, one of the symptoms of allergic contact dermatitis (p < 0.0001). It had no significant effect on the number of scratches. It reduced serum IL-17 levels (p < 0.01). It alleviated local inflammation by suppressing CD8+ T lymphocyte and neutrophil infiltration. Conclusions: It was concluded that remote ischemic postconditioning may alleviate the symptoms of allergic contact dermatitis by suppressing CD8(+ )T lymphocyte and neutrophil infiltration and reducing IL-17 secretion.en_US
dc.description.sponsorshipWe thank Dilsad Erumit, Mehmet Zahid Cetinkaya, Buse Cevik, and Kubra Duvan-Aydemir for their support.en_US
dc.description.sponsorshipWe thank Dilsad Erumit, Mehmet Zahid Cetinkaya, Buse Cevik, and Kubra Duvan-Aydemir for their support.en_US
dc.identifier.doi10.3390/medicina59101816
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue10en_US
dc.identifier.pmid37893534en_US
dc.identifier.scopus2-s2.0-85175245843en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/medicina59101816
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18285
dc.identifier.volume59en_US
dc.identifier.wosWOS:001092623500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMedicina-Lithuaniaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllergic Contact Dermatitisen_US
dc.subjectRemote Ischemic Postconditioningen_US
dc.subjectInflammationen_US
dc.subjectPruritusen_US
dc.subjectScratching Behavioren_US
dc.subjectCd8(+) T-Cellsen_US
dc.subjectSensitivityen_US
dc.subjectElicitationen_US
dc.subjectMiceen_US
dc.titleAnti-Inflammatory and Antipruritic Effects of Remote Ischaemic Postconditioning in a Mouse Model of Experimental Allergic Contact Dermatitisen_US
dc.typeArticleen_US

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